Medical Terminology Daily (MTD) is a blog sponsored by Clinical Anatomy Associates, Inc. as a service to the medical community. We post anatomical, medical or surgical terms, their meaning and usage, as well as biographical notes on anatomists, surgeons, and researchers through the ages. Be warned that some of the images used depict human anatomical specimens.

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A Moment in History

Larsen

William J. Larsen, PhD
(1942-2000)

An American scientist, Dr. Larsen was a gifted scientist, consistently producing research at the forefront of cell, developmental, and reproductive biology. Early in his career he published a landmark paper that conclusively established mitochondrial fission as the mechanism of mitochondrial biogenesis. He went on to become the first to demonstrate the endocytosis of gap junctions. Moreover, his work on the hormonal regulation of gap junction formation and growth culminated in an authoritative review article in Tissue and Cell, “Structural Diversity of Gap Junctions (1988)”, which became a citation classic.

Throughout his 25 year teaching career, his sixty-seven peer reviewed publications—not to mention numerous invited reviews, abstracts, and book chapters—covered a wide range of research areas including adrenal cortical tumor cells, human ovarian carcinomas, preterm labor, cumulus expansion, oocyte maturation, ovulation, folliculogenesis, and in-vitro fertilization.

In addition to his many contributions to basic research, Dr. Larsen loved to teach and was much appreciated by his students. His exceptional ability was reflected in the four teaching awards he received as a professor at the University of Cincinnati.

Notably, he was the author of Human Embryology, a textbook for medical students that was the first to incorporate modern experimental research into a subject that had traditionally been taught in a strictly descriptive style. On its initial publication in 1998 it was hailed as, “a magnificent book…” by the European Medical Journal. With the release of the fourth edition in 2008, the book was renamed “Larsen’s Human Embryology” in recognition of Dr. Larsen's place as the originator of this revolutionary text. This book is today in it's 6th Edition.

His stellar scientific career would be enough for most people, but Dr. Larsen pursued his numerous and varied interests with such extraordinary passion, energy, and skill that he seemed to have more hours in a day than the ordinary person. He was fascinated with the American Southwest and studied and collected traditional arts and crafts of the Hopi, Zuni, and Navajo peoples. He was a woodworker who built three harpsichords and a fortepiano for his wife, and, with his two children, over 100 pieces of gallery-quality furniture. In addition, he loved to regale his friends, colleagues, and students with jokes and stories, and to share his love for gourmet cooking.

The William J. Larsen Distinguished Lecture Series

An annual lecture series was created for the Department of Cancer & Cell Biology at the University of Cincinnati to honor Dr. Larsen's research which was at the forefront of cell developmental and reproductive biology. This series recognizes forward-thinking research scientists in the field of developmental biology and asks that they share their research and findings with students and faculty of the University of Cincinnati, College of Medicine.

Personal note: I had the opportunity to meet and attend Dr. Larsen’s embryology lectures as he and I worked in the Anatomy, Embryology, and Histology program at the University of Cincinnati Medical College. Unfortunately, I never had the opportunity to have Dr. Larsen sign my personal copy of his book. He is sorely missed, Dr. Miranda

Sources:

1. "The William J. Larsen Distinguished Lecture Series" University of Cincinnati, College of Medicine.
2. https://www.larsenbooks.com
3. 2022 Larsen Lecture Series brochure (download here)
4. Dr. Larsen's family personal communications


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Sir William Osler


This article is part of the series "A Moment in History" where we honor those who have contributed to the growth of medical knowledge in the areas of anatomy, medicine, surgery, and medical research.To search all the articles in this series, click here.
Sir William Osler (1849-1919). William Osler was born in Bond Head, Canada, in what today is known as Ontario, of English parents. He started his college studies to become a minister, but realizing his true vocation was in medicine, he entered the Toronto School of Medicine, earning his medical degree in 1872.

Osler completed postgraduate studies in Europe, returning as a Professor at the McGill University. In 1884 he moved to Philadelphia to the University of Pennsylvania. In 1889 he left to become Physician-in-Chief and one of the founders of the newly-built John Hopkins hospital. His contributions to this new hospital and the American medical education are innumerable. Dr. Osler initiated the residency programs used today, as well as the programs of third and fourth year medical students in bedside patient rounds.

A prolific writer, Dr. Osler penned over 1,500 articles, monographs, and books, some of which are famous. His “Principles and Practice of Medicine” was published for a record 17 editions and 76 years (1892 -1968)! One of his most famous addresses is “Aequanimitas”, which he delivered when leaving the University of Pennsylvania.

Sir William Osler
Original image courtesy of "Images from the History of Medicine" at  www.nih.gov
In 1905 Dr. Osler accepted the position of Royal Chair of Medicine at Oxford, in England, and in 1911 he was awarded the title of “Sir William Osler”.

Personal Note: In June 1999, I had the opportunity to visit the collection of the John Martin Rare Book Room at the University of Iowa Medical School. I was allowed to read and handle original copies of the Fabrica and the Epitome by Vesalius as well as other original and rare medical books, including De Muto Cordis, by William Harvey. The books I had the opportunity to review were placed on an antique desk that belonged to Sir William Osler. A moment that has stayed with me, as it was the confluence of great individuals: Andreas Vesalius, the anatomist; William Harvey, the physiologist, and Sir William Osler, the medical educator. Dr. Miranda

Sources:
“Sir William Osler, M.D., C.M.” Sarik, J. Yeo, Ch.Pinckney J. The American Surgeon78.4 (2012): 385-7.
“Sir William Osler and gastroenterology” Chaun H. Can J Gastroenterol (2010) 24:10 615-618
“Sir William Osler (1849-1919)” Haas, LF J Neurol Neurosurg Psychiatry 1999 67: 137
“Sir William Osler (1849-1919)”Christian, HA Proc Amer Acad Arts Sci (1922) 496-499

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