Avicenna

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A Moment in History

Georg Eduard Von Rindfleisch
(1836 – 1908)

German pathologist and histologist of Bavarian nobility ancestry. Rindfleisch studied medicine in Würzburg, Berlin, and Heidelberg, earning his MD in 1859 with the thesis “De Vasorum Genesi” (on the generation of vessels) under the tutelage of Rudolf Virchow (1821 - 1902). He then continued as a assistant to Virchow in a newly founded institute in Berlin. He then moved to Breslau in 1861 as an assistant to Rudolf Heidenhain (1834–1897), becoming a professor of pathological anatomy. In 1865 he became full professor in Bonn and in 1874 in Würzburg, where a new pathological institute was built according to his design (completed in 1878), where he worked until his retirement in 1906.

He was the first to describe the inflammatory background of multiple sclerosis in 1863, when he noted that demyelinated lesions have in their center small vessels that are surrounded by a leukocyte inflammatory infiltrate.

After extensive investigations, he suspected an infectious origin of tuberculosis - even before Robert Koch's detection of the tuberculosis bacillus in 1892. Rindfleisch 's special achievement is the description of the morphologically conspicuous macrophages in typhoid inflammation. His distinction between myocardial infarction and myocarditis in 1890 is also of lasting importance.

Associated eponyms

"Rindfleisch's folds": Usually a single semilunar fold of the serous surface of the pericardium around the origin of the aorta. Also known as the plica semilunaris aortæ.

"Rindfleisch's cells": Historical (and obsolete) name for eosinophilic leukocytes.

Personal note: G. Rindfleisch’s book “Traité D' Histologie Pathologique” 2nd edition (1873) is now part of my library. This book was translated from German to French by Dr. Frédéric Gross (1844-1927) , Associate Professor of the Medicine Faculty in Nancy, France. The book is dedicated to Dr. Theodore Billroth (1829-1894), an important surgeon whose pioneering work on subtotal gastrectomies paved the way for today’s robotic bariatric surgery. Dr. Miranda.

Sources:
1. "Stedmans Medical Eponyms" Forbis, P.; Bartolucci, SL; 1998 Williams and Wilkins
2. "Rindfleisch, Georg Eduard von (bayerischer Adel?)" Deutsche Biographie
3. "The pathology of multiple sclerosis and its evolution" Lassmann H. (1999) Philos Trans R Soc Lond B Biol Sci. 354 (1390): 1635–40.
4. “Traité D' Histologie Pathologique” G.E.
Rindfleisch 2nd Ed (1873) Ballieres et Fils. Paris, Translated by F Gross

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Details: Written by: Efrain A. Miranda, Ph.D.; Published: December 30, 2013; Hits: 4451

This article is part of the series "A Moment in History" where we honor those who have contributed to the growth of medical knowledge in the areas of anatomy, medicine, surgery, and medical research.

Avicenna

Avicenna (980 AD – 1037 AD) Persian physician, philosopher, mathematician, naturalist, geologist, musical theorist, astronomer and poet. Ab? Al? al-Hysayn ibn-‘Abd-All?h ibn-S?na, also known as “ibn-S?na“ and as “Avicenna” was born in Afshaneh, near the city of Bokhara (in old Persia, what today is Iran) in 980AD.

Intellectually gifted, Avicenna studied philosophy and the Islam religion, with early studies in medicine. By age 18 he was already a famous physician. With access to the royal library Avicenna continued his studies and traveled through what today is Iran. Avicenna had government positions, becoming prime minister. Jailed for political reasons Avicenna wrote a large number of his medical, philosophical, and astronomical publications while in jail.

Of over 450 total medical books attributed to Avicenna, his most famous publication was the “al-Qanun-fi-al-Tibb” or the “Canon of Medicine”, consisting of five books on principles of medicine, diseases, drugs, and compound medicines. The Canon was translated into Latin and later into other languages, remaining an important book for at least until the 16th century.

He used the term “vermis” and spoke of the “tailed nucleus”, known to us as the “caudate nucleus”. Avicenna died in 1037AD at 57 years of age. He was buried in the city of Hamadh?n, where his tomb still exists. Avicenna has been called the “prince of physicians”.

Sources
1. “Avicenna” Koontz AR JAMA. 1962;179(1):99
2. "Honoring Avicenna, the Great Persian Physician on the World's Postage Stamps". Afshar, A. Arch Iranian Med (1029-2977), 13 (5), 447
3. "Avicenna and the Canon of Medicine: A millennial tribute" West J Med 133:367-370, Oct 1980
4. “Avicenna (980–1037 AD) Zargaran, A, et al. J Neurol (2012) 259:389–390 5. “Avicenna” JAMA 177:704 (1961)
Original image courtesy of NLM

Avicenna

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