Medical Terminology Daily - Est. 2012

Medical Terminology Daily (MTD) is a blog sponsored by Clinical Anatomy Associates, Inc. as a service to the medical community. We post anatomical, medical or surgical terms, their meaning and usage, as well as biographical notes on anatomists, surgeons, and researchers through the ages. Be warned that some of the images used depict human anatomical specimens.

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A Moment in History

William S. Halsted, MD

William S. Halsted, MD
(1852 – 1922)

American anatomist, teacher, and surgeon, William Stewart Halsted was born in New York City, USA to a wealthy family of English origin. His father was involved in charitable work and Governor and trustee to a city hospital. Not a brilliant student initially, Halsted took an undergraduate in Liberal Arts in Yale, CT., after which he entered the Medical College of Physicians at the Columbia College, where he excelled.

As a second-year medical student Halsted applied and obtained a position in surgery at a local hospital. In here he learned about Lister’s antiseptic technique and became an adamant proponent of it to reduce infection. In 1877 Halsted obtained his MD. After a short time as House Physician at the New York Hospital, Halsted traveled to Europe to further his education studying for two years at the Universities of Vienna, Leipzig, and W?rzburg.

Besides being at the forefront of surgical and antiseptic techniques (introducing the use of rubber gloves in surgery), Halsted was extremely concerned with the way medical students were taught in the US. He pioneered bedside clinical round discussions with the medical students after two years of basic sciences studies. Halsted developed the idea of a patient chart; he also developed the residency program for medical students in use today.

Halsted is probably the most influential researcher and surgeon at the turn of the century. He dedicated time to the study of intestinal anastomoses and the use of silk as a suture material. His experimental work in 1887 proved that the inclusion of the submucosa layer in an anastomosis was mandatory, as well that a single layered anastomosis was enough to attain closure. Perhaps Halsted’s most important contribution was the application and use of the scientific method to surgical questions. Halsted’s principles, also known as  "Halsted's Rules of Surgery", set the standards used today in surgical suturing and surgical stapling.

He also pioneered the development and surgical techniques for radical mastectomy as a treatment for breast cancer.

As a side effect of this studied in anesthesia and the use of cocaine for anesthesia, Halsted became addicted to this substance, a problem that followed him through the years. Without impairing his capacity as a researcher and a surgeon, Halsted eventually recovered. He died in Baltimore in 1922 as a complication to surgery.

Sources:
1. Dubay, A. D., & Franz, G. M. (2003). Acute Wound Healing: The Biology of Acute Wound Failure. Surg Clin NA, 83, 463-481.
2. Halsted, W. S. (1887). Circular Suture of the Intestine - An Experimental Study. Am J Med Sci, 436-461.
3. “William Stewart Halsted: his life and contributions to surgery” Osborne, P. Lancet Oncol 2007; 8: 256–65
4. “William Stewart Halsted: Surgical pioneer” Burress, P Endoc Today (2010), 8: (2) 22
5. “William Stewart Halsted (1852–1922) Neurological stamp” Haas, LF J Neurol Neurosurg Psych 2000;69:641
Original image courtesy of "Images from the History of Medicine" at  www.nih.gov


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Walter Eduard Carl Koch (1880–1962), German physician, anatomist, and pathologist. Born in Dortmund, Germany, studied medicine at the University of Freiburg and the Kaiser Wilhelm Academy in Berlin, attaining his doctorate in 1907.

He served as a military physician, and later at the Kaiser Wilhelm Academy and in Berlin. Koch specialized in pathology and pathological anatomy and was appointed professor in 1922. Later he became head of the Pathology Department at the Westend Hospital in Berlin and held academic positions after World War II, including a professorship at the newly reconstituted Free University of Berlin. He died in 1962.

He is remembered by the eponymous “triangle of Koch, “site for the atrioventricular node. Although he never referred to this area as a triangle, or used his name to refer to this area, he described it as we know it today in his 1922 publication “Der Funktionelle Bau des Menschlichen Herzens” (The functional structure of the human heart).

1922 original image by Koch showing the area for the AV node
Plate X.1 by Walter EC Koch (1922)

In Plate 10.1 Koch shows a photograph of the right atrium where he has drawn the “Tawara’schen Knotten”- an early name for the atrioventricular node (knot of Tawara) – and he describes it as follows: “Vorhofsfeld im rechten Vorhof, vom Sinusstreifen als Fortsetzung der Valvula Eustachii, von der Coronarvenenmündung und dem Ansatz der Tricuspidalisiklappe umsäumt, in weichem der Anfangstait des Reizleitungssystems (schematisch eingezeichnet) gelegen ist: Sinusstreifen und Tricuspidalis treffen sich an der Pars membranacea dort, wo der Stamm den Knoten verläßt” (The atrial region in the right atrium, bordered by the sinoatrial band, a continuation of the Eustachian valve, by the coronary vein (sinus) orifice and the insertion of the tricuspid valve, in which the initial stage of the conduction system (schematically shown) is located: the sinoatrial sinus and the tricuspid valve meet at the pars membranacea where the trunk leaves the node.) The handwriting on the image is by Koch himself.

Note that Koch does not mention the tendon of Todaro as a landmark in this description (although Todaro’s tendon is mentioned in this publication), and Koch calls it the “sinoatrial band").

The term "triangle of Koch" refers to a triangular area in the right atrium with defined anatomical boundaries:

• Medial border: the tendon of Todaro
• Inferior border: the tricuspid valve leaflet
• Posterior border: the orifice of the coronary sinus.

The apex of this triangle corresponds to the location of the atrioventricular node.

Note: In spite of my efforts, I could not find a photograph or a portrait of Walter E.C. Koch. Dr. Miranda.

Sources
1. "Remembering the canonical discoverers of the core components of the mammalian cardiac conduction system: Keith and Flack, Aschoff and Tawara, His, and Purkinje" Icilio Cavero and Henry Holzgrefe Advances in Physiology Education 2022 46:4, 549-579. 
2. "Tratado de Anatomia Humana" Testut et Latarjet 8th Ed. 1931 Salvat Editores, Spain 
3. Anderson RH, Sánchez-Quintana D, Nevado-Medina J, Spicer DE, Tretter JT, Lamers WH, Hu Z, Cook AC, Sternick EB, Katritsis DG. . The Anatomy of the Atrioventricular Node. J of Cardiovasc Development and Disease. 2025; 12(7):245. 
4. Koch, Walter “Der Funktionelle Bau des Menschlichen Herzens” Urban & Schwarzenberg. 1922. Berlin