Medical Terminology Daily (MTD) is a blog sponsored by Clinical Anatomy Associates, Inc. as a service to the medical community. We post anatomical, medical or surgical terms, their meaning and usage, as well as biographical notes on anatomists, surgeons, and researchers through the ages. Be warned that some of the images used depict human anatomical specimens.

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A Moment in History

Larsen

William J. Larsen, PhD
(1942-2000)

An American scientist, Dr. Larsen was a gifted scientist, consistently producing research at the forefront of cell, developmental, and reproductive biology. Early in his career he published a landmark paper that conclusively established mitochondrial fission as the mechanism of mitochondrial biogenesis. He went on to become the first to demonstrate the endocytosis of gap junctions. Moreover, his work on the hormonal regulation of gap junction formation and growth culminated in an authoritative review article in Tissue and Cell, “Structural Diversity of Gap Junctions (1988)”, which became a citation classic.

Throughout his 25 year teaching career, his sixty-seven peer reviewed publications—not to mention numerous invited reviews, abstracts, and book chapters—covered a wide range of research areas including adrenal cortical tumor cells, human ovarian carcinomas, preterm labor, cumulus expansion, oocyte maturation, ovulation, folliculogenesis, and in-vitro fertilization.

In addition to his many contributions to basic research, Dr. Larsen loved to teach and was much appreciated by his students. His exceptional ability was reflected in the four teaching awards he received as a professor at the University of Cincinnati.

Notably, he was the author of Human Embryology, a textbook for medical students that was the first to incorporate modern experimental research into a subject that had traditionally been taught in a strictly descriptive style. On its initial publication in 1998 it was hailed as, “a magnificent book…” by the European Medical Journal. With the release of the fourth edition in 2008, the book was renamed “Larsen’s Human Embryology” in recognition of Dr. Larsen's place as the originator of this revolutionary text. This book is today in it's 6th Edition.

His stellar scientific career would be enough for most people, but Dr. Larsen pursued his numerous and varied interests with such extraordinary passion, energy, and skill that he seemed to have more hours in a day than the ordinary person. He was fascinated with the American Southwest and studied and collected traditional arts and crafts of the Hopi, Zuni, and Navajo peoples. He was a woodworker who built three harpsichords and a fortepiano for his wife, and, with his two children, over 100 pieces of gallery-quality furniture. In addition, he loved to regale his friends, colleagues, and students with jokes and stories, and to share his love for gourmet cooking.

The William J. Larsen Distinguished Lecture Series

An annual lecture series was created for the Department of Cancer & Cell Biology at the University of Cincinnati to honor Dr. Larsen's research which was at the forefront of cell developmental and reproductive biology. This series recognizes forward-thinking research scientists in the field of developmental biology and asks that they share their research and findings with students and faculty of the University of Cincinnati, College of Medicine.

Personal note: I had the opportunity to meet and attend Dr. Larsen’s embryology lectures as he and I worked in the Anatomy, Embryology, and Histology program at the University of Cincinnati Medical College. Unfortunately, I never had the opportunity to have Dr. Larsen sign my personal copy of his book. He is sorely missed, Dr. Miranda

Sources:

1. "The William J. Larsen Distinguished Lecture Series" University of Cincinnati, College of Medicine.
2. https://www.larsenbooks.com
3. 2022 Larsen Lecture Series brochure (download here)
4. Dr. Larsen's family personal communications


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Bernhard Siegfried Albinus


This article is part of the series "A Moment in History" where we honor those who have contributed to the growth of medical knowledge in the areas of anatomy, medicine, surgery, and medical research.To search all the articles in this series, click here.

Bernhard Siegfried Albinus (1697-1770). German-Dutch physician, surgeon, and anatomist, Albinus was born in Frankfurt an der Oder, but lived most of his life in Leyden, in Holland, his adopted country. His real name was Bernhard Siegfried Weiss, which means “white” in German, the Latin version of which is “albus”, from where derives his Latinized name “Albinus”.

His father was also a physician, Bernard (or Bernhard) Weiss (1653 – 1721). He also took the last name Albinus, which makes following their history and genealogy a bit difficult.

Albinus moved to Leyden (Leiden) when he was only five years old, excelling at his studies and entering the University of Leyden at 12. He later moved to Paris, France to continue his studies on anatomy and surgery. He received his medical degree in 1719.

He began work at the University of Leyden as a Professor of Anatomy and Surgery, where he continued working until his death in 1770. He is considered one the most well-known anatomists of the 18th century.

Bernhard Siegfried Albinus
Because of his work with his colleague Herman Boerhaave (1668-1738), Albinus came in contact with Jan Wandelaar (1690-1759) an artist and engraver. It was this collaboration and the art of Jan Wandelaar which have made Albinus’ books and illustration famous. Albinus was criticized for the luscious, detailed, and sometimes strange backgrounds of his anatomical images, yet he defended Jan Wandelaar and his artistic expression. Albinus and Jan Wandelaar were dedicated to the faithful reproduction of anatomy in their publications, developing a grid system to reduce errors in production and printing.

During his tenure, Albinus was twice appointed Rector of the University and President of the College of Surgeons of Leyden. During this time, he became aware of the discovery of the copper plates created by Eustachius’ and lost for over a hundred years. In 1744 he published the plates in the book “Explanation of the Anatomical Tables of Eustachius “with his comments, stressing the fact that these images were better than those of Vesalius, published in 1543. This is no surprise, as Vesalius’ images were woodcuts, done before the technique of printing with copper plates became popular.

Although not well-known, Albinus’ name is eponymically attached to the risorius and scalenus minimus muscles. His famous publications include  “Historia muscolorum hominis”  in 1734),  “Icones ossium foetus humani” in   1737, “Tabulae sceleti et musculorum corporis humani” in 1749, etc.

Some of Albinus and Jan Wandelaar can be seen in the following links that will open is separate pages:

IMAGE 1; IMAGE 2; IMAGE 3; IMAGE 4

Sources:
1. "Bernard Siegfried Albinus (1697-1770), German-Dutch anatomist" JAMA (1966), 196 (10): 910
2.“Bartholomeo Eustachio – The Third Man: Eustachius Published By Albinus” Fahrer, M. Ann Anat 187 (2005) 555—573
3. “Attic perfection in anatomy: Bernhard Siegfried Albinus (1697–1770) and Samuel Thomas Soemmerring (1755–1830)” Hildebrand, R. Ann Anat 187 (2005) 555—573
4. “Two Conceptions of the Human Form: Bernard Siegfried Albinus and Andreas Vesalius” Elkins, J. Artibus et Historiae, 7:14 (1986)  91-106
5. “Bartolomeo Eustachio: His Influence on Albinus and the Anatomical Models at La Specola, Florence” Hilloowala, R. J Hist Med All Sci (1986); 41 (4): 442 -462
Original image courtesy of Images from the History of Medicine 

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