Medical Terminology Daily (MTD) is a blog sponsored by Clinical Anatomy Associates, Inc. as a service to the medical community. We post anatomical, medical or surgical terms, their meaning and usage, as well as biographical notes on anatomists, surgeons, and researchers through the ages. Be warned that some of the images used depict human anatomical specimens.

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A Moment in History

Larsen

William J. Larsen, PhD
(1942-2000)

An American scientist, Dr. Larsen was a gifted scientist, consistently producing research at the forefront of cell, developmental, and reproductive biology. Early in his career he published a landmark paper that conclusively established mitochondrial fission as the mechanism of mitochondrial biogenesis. He went on to become the first to demonstrate the endocytosis of gap junctions. Moreover, his work on the hormonal regulation of gap junction formation and growth culminated in an authoritative review article in Tissue and Cell, “Structural Diversity of Gap Junctions (1988)”, which became a citation classic.

Throughout his 25 year teaching career, his sixty-seven peer reviewed publications—not to mention numerous invited reviews, abstracts, and book chapters—covered a wide range of research areas including adrenal cortical tumor cells, human ovarian carcinomas, preterm labor, cumulus expansion, oocyte maturation, ovulation, folliculogenesis, and in-vitro fertilization.

In addition to his many contributions to basic research, Dr. Larsen loved to teach and was much appreciated by his students. His exceptional ability was reflected in the four teaching awards he received as a professor at the University of Cincinnati.

Notably, he was the author of Human Embryology, a textbook for medical students that was the first to incorporate modern experimental research into a subject that had traditionally been taught in a strictly descriptive style. On its initial publication in 1998 it was hailed as, “a magnificent book…” by the European Medical Journal. With the release of the fourth edition in 2008, the book was renamed “Larsen’s Human Embryology” in recognition of Dr. Larsen's place as the originator of this revolutionary text. This book is today in it's 6th Edition.

His stellar scientific career would be enough for most people, but Dr. Larsen pursued his numerous and varied interests with such extraordinary passion, energy, and skill that he seemed to have more hours in a day than the ordinary person. He was fascinated with the American Southwest and studied and collected traditional arts and crafts of the Hopi, Zuni, and Navajo peoples. He was a woodworker who built three harpsichords and a fortepiano for his wife, and, with his two children, over 100 pieces of gallery-quality furniture. In addition, he loved to regale his friends, colleagues, and students with jokes and stories, and to share his love for gourmet cooking.

The William J. Larsen Distinguished Lecture Series

An annual lecture series was created for the Department of Cancer & Cell Biology at the University of Cincinnati to honor Dr. Larsen's research which was at the forefront of cell developmental and reproductive biology. This series recognizes forward-thinking research scientists in the field of developmental biology and asks that they share their research and findings with students and faculty of the University of Cincinnati, College of Medicine.

Personal note: I had the opportunity to meet and attend Dr. Larsen’s embryology lectures as he and I worked in the Anatomy, Embryology, and Histology program at the University of Cincinnati Medical College. Unfortunately, I never had the opportunity to have Dr. Larsen sign my personal copy of his book. He is sorely missed, Dr. Miranda

Sources:

1. "The William J. Larsen Distinguished Lecture Series" University of Cincinnati, College of Medicine.
2. https://www.larsenbooks.com
3. 2022 Larsen Lecture Series brochure (download here)
4. Dr. Larsen's family personal communications


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Raymond de Vieussens


This article is part of the series "A Moment in History" where we honor those who have contributed to the growth of medical knowledge in the areas of anatomy, medicine, surgery, and medical research.To search all the articles in this series, click here.

Raymond de Vieussens (c.1635 – 1715). French anatomist and physician. His exact date and place of birth are uncertain, some place him being born in the area of Le Vigan in France and the date for some authors as late as 1641.

What we do know is that he studied at the University of Montpellier where he graduated from his medical studies in 1670. He became a physician at the Hôtel Dieu Saint-Eloi in Montpellier. He later became head physician at the same hospital and apparently maintained this position for the rest of his life. His studies on the anatomy of the heart and lymphatic system were pioneers for the time, as were his studies on the anatomy of the nervous system.

Vieussens was a prolific writer. Among his works in 1706, he published “Nouvelles Découvertes sur le Coeur” (New Discoveries on the Heart) followed by “Traité Nouveau de la Structure et Des causes du Mouvement Naturel du Coeur” (New Treaties on the Structure and Cause of the Natural Movement of the Heart) in 1715. In these books he presented detailed anatomy of the lymphatic system and blood vessels of the heart, as well as his theories on the movement of the heart. In his work, he did the first accurate description of mitral stenosis and aortic disease.

 Vieussens1

One of his greatest works was “Neurographia Universalis”, published in 1684 in Lyons, France. In this book Vieussens describes the structure of the nervous system with emphasis on the pathways of the white substance, which we know today is formed by bundles of neuronal axons. He accurately described the internal structure of the cerebellum and other structures that today bear his name. Unfortunately Vieussens attempted to describe the physiology of the brain with little factual support, developing wild theories, including the statement that he had found the “fluid of the nerves”.

Some of Vieussens’ work was published posthumously by his family and colleagues. Today, many eponyms remember Vieussens’ name, here are some of them:

Valve of Vieussens: A valve found at the distal end of the great cardiac vein, where it empties into the coronary sinus
Ring of Vieussens: Name for and anatomical variation in the heart, an anastomotic communication between two conal arteries, one arising from the right coronary artery, the other arising from the left anterior descending artery (LAD)
• Centrum of Vieussens: A term that describes the mass of white matter at the center of each cerebral hemisphere
• Ring of Vieussens: Eponymic term for the limbus fossa ovalis, a raised muscular ring surrounding the fossa ovalis in the heart
• Valve of Vieussens: A thin veil of tissue between the superior cerebellar peduncles, forming part of the roof of the 4th ventricle. This is known as the superior medullary vellum and may have some sparse cerebellar tissue on it
• The ventricle of Vieussens: The name of a cavity found in the case where the septum pellucidum is double. The septum pellucidum is a membrane that separates the lateral ventricles of the brain in the midline

If you hover with your mouse over the image of young Vieussens you will see another image of Vieussens at 65. 

Original images courtesy of National Library of Medicine. 

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