Medical Terminology Daily - Est. 2012

Medical Terminology Daily (MTD) is a blog sponsored by Clinical Anatomy Associates, Inc. as a service to the medical community. We post anatomical, medical or surgical terms, their meaning and usage, as well as biographical notes on anatomists, surgeons, and researchers through the ages. Be warned that some of the images used depict human anatomical specimens.

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A Moment in History

Georg Eduard Von Rindfleisch

Georg Eduard Von Rindfleisch
(1836 – 1908)

German pathologist and histologist of Bavarian nobility ancestry. Rindfleisch studied medicine in Würzburg, Berlin, and Heidelberg, earning his MD in 1859 with the thesis “De Vasorum Genesi” (on the generation of vessels) under the tutelage of Rudolf Virchow (1821 - 1902). He then continued as a assistant to Virchow in a newly founded institute in Berlin. He then moved to Breslau in 1861 as an assistant to Rudolf Heidenhain (1834–1897), becoming a professor of pathological anatomy. In 1865 he became full professor in Bonn and in 1874 in Würzburg, where a new pathological institute was built according to his design (completed in 1878), where he worked until his retirement in 1906.

He was the first to describe the inflammatory background of multiple sclerosis in 1863, when he noted that demyelinated lesions have in their center small vessels that are surrounded by a leukocyte inflammatory infiltrate.

After extensive investigations, he suspected an infectious origin of tuberculosis - even before Robert Koch's detection of the tuberculosis bacillus in 1892. Rindfleisch 's special achievement is the description of the morphologically conspicuous macrophages in typhoid inflammation. His distinction between myocardial infarction and myocarditis in 1890 is also of lasting importance.

Associated eponyms

"Rindfleisch's folds": Usually a single semilunar fold of the serous surface of the pericardium around the origin of the aorta. Also known as the plica semilunaris aortæ.

"Rindfleisch's cells": Historical (and obsolete) name for eosinophilic leukocytes.

Personal note: G. Rindfleisch’s book “Traité D' Histologie Pathologique” 2nd edition (1873) is now part of my library. This book was translated from German to French by Dr. Frédéric Gross (1844-1927) , Associate Professor of the Medicine Faculty in Nancy, France. The book is dedicated to Dr. Theodore Billroth (1829-1894), an important surgeon whose pioneering work on subtotal gastrectomies paved the way for today’s robotic bariatric surgery. Dr. Miranda.

Sources:
1. "Stedmans Medical Eponyms" Forbis, P.; Bartolucci, SL; 1998 Williams and Wilkins
2. "Rindfleisch, Georg Eduard von (bayerischer Adel?)" Deutsche Biographie
3. "The pathology of multiple sclerosis and its evolution" Lassmann H. (1999)  Philos Trans R Soc Lond B Biol Sci. 354 (1390): 1635–40.
4. “Traité D' Histologie Pathologique” G.E.
Rindfleisch 2nd Ed (1873) Ballieres et Fils. Paris, Translated by F Gross


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Andreas Vesalius Bruxellensis
Click for Vesalius' biography 

UPDATED: We have discussed many times on this blog the importance of Andreas Vesalius (1514 – 1564), his impact on modern science and anatomy, and the influence of his opus magnum publication in 1543, the Fabrica. The complete name of this publication is “De Humani Corporis Fabrica, Libri Septem” (Seven books on the structure of the human body).

Harvey Cushing wrote in his Vesalius bio-bibliography of 1943:”As a book, the Fabrica has been probably more admired and less read than any publication of equal significance in the history of science”.

The first (1543) and second (1555) editions of the Fabrica were published in Basel, Switzerland by Johannes Oporinus (1507 – 1568). With few exceptions, the Fabrica was sold as an unbound book and it was the owner’s responsibility to bind the book. One of the exceptions was the sumptuous purple silk-bound presentation copy delivered to the Emperor Charles V. As an interesting note, a Fabrica was discovered in Canada that was heavily annotated and as such had a low value. Who wants a book that of this importance that is so heavily hand-written? Analysis of the writing and style indicate that this copy belonged to Vesalius himself and was most probably the basis for a third edition that was never published. The annotations are used in the "New Fabrica" and if you are interested,  here is a PDF file of a 2014 article on this topic.

Today we do not know how many books were actually printed as part of the first and the second edition of the Fabrica. Because of the time passed, lost or damaged books, during the last century efforts have been made to inventory the number of Fabricas still in existence, in studies made by Cushing in 1943 and Horowiz and Collins in 1984.The latest effort to account for the total number of these books was made by Stephen N. Joffe, MD, and Veronica Buchanan, MA in 2015 for both the 1543 and the 1555 editions of the Fabrica. Their papers were presented in February 2015 at the interdisciplinary symposium “Vesalius and the Invention of the Modern Body” in St. Louis, MO.

Dr. Joffe  is the author of the book “Andreas Vesalius: The Making, the Madman, and the Myth”. Veronica Buchanan is the Archivist at the University of Cincinnati Henry R. Winkled Center for the History of the Health Professions.

The authors of these papers estimate that there are 64 complete copies surviving of the estimated 300 – 500 first edition printed in 1543. While a similar printing run is estimated for the 1555 edition, only 58 complete copies survive in the USA The papers can be read and downloaded on the following links:

"Updated Census in USA of First Edition of Andreas Vesalius’ ‘De Humani Corporis Fabrica’ of 1543”
READ DOWNLOAD 

 “An Updated Census of the Edition of 1555 of Andreas Vesalius’ De Humani Corporis Fabrica in the United States of America” READ DOWNLOAD

Note: The following link was sent to me by Dr. Elizabeth Murray and refers to the study by Joffe and Buchanan. The article “Accounting for an Historic Text” is from the University of Cincinnati Newsletter. Dr. Miranda

Sources
1. “Updated Census in USA of First Edition of Andreas Vesalius’ ‘De Humani Corporis Fabrica’ of 1543” Joffe, SN; Buchanan V. International Archives of Medicine; 2015: 8:1
2. “An Updated Census of the Edition of 1555 of Andreas Vesalius’ De Humani Corporis Fabrica in the United States of America” International Archives of Medicine; 2015: 8:1
3. Cushing, Harvey: A Bio-bibliography of Andreas Vesalius 2nd edition. Hamden: Conn.
4. Garrison, Daniel H., Hast, Malcom H.: Andreas Vesalius: The Fabric of the Human Body. Published S. Karger, Basel; 2014
5. "Andreas Vesalius; The Making, the Madman, and the Myth" Joffe, Stephen N. Persona Publishing 2009