Medical Terminology Daily - Est. 2012

Medical Terminology Daily (MTD) is a blog sponsored by Clinical Anatomy Associates, Inc. as a service to the medical community. We post anatomical, medical or surgical terms, their meaning and usage, as well as biographical notes on anatomists, surgeons, and researchers through the ages. Be warned that some of the images used depict human anatomical specimens.

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A Moment in History

William S. Halsted, MD

William S. Halsted, MD
(1852 – 1922)

American anatomist, teacher, and surgeon, William Stewart Halsted was born in New York City, USA to a wealthy family of English origin. His father was involved in charitable work and Governor and trustee to a city hospital. Not a brilliant student initially, Halsted took an undergraduate in Liberal Arts in Yale, CT., after which he entered the Medical College of Physicians at the Columbia College, where he excelled.

As a second-year medical student Halsted applied and obtained a position in surgery at a local hospital. In here he learned about Lister’s antiseptic technique and became an adamant proponent of it to reduce infection. In 1877 Halsted obtained his MD. After a short time as House Physician at the New York Hospital, Halsted traveled to Europe to further his education studying for two years at the Universities of Vienna, Leipzig, and W?rzburg.

Besides being at the forefront of surgical and antiseptic techniques (introducing the use of rubber gloves in surgery), Halsted was extremely concerned with the way medical students were taught in the US. He pioneered bedside clinical round discussions with the medical students after two years of basic sciences studies. Halsted developed the idea of a patient chart; he also developed the residency program for medical students in use today.

Halsted is probably the most influential researcher and surgeon at the turn of the century. He dedicated time to the study of intestinal anastomoses and the use of silk as a suture material. His experimental work in 1887 proved that the inclusion of the submucosa layer in an anastomosis was mandatory, as well that a single layered anastomosis was enough to attain closure. Perhaps Halsted’s most important contribution was the application and use of the scientific method to surgical questions. Halsted’s principles, also known as  "Halsted's Rules of Surgery", set the standards used today in surgical suturing and surgical stapling.

He also pioneered the development and surgical techniques for radical mastectomy as a treatment for breast cancer.

As a side effect of this studied in anesthesia and the use of cocaine for anesthesia, Halsted became addicted to this substance, a problem that followed him through the years. Without impairing his capacity as a researcher and a surgeon, Halsted eventually recovered. He died in Baltimore in 1922 as a complication to surgery.

Sources:
1. Dubay, A. D., & Franz, G. M. (2003). Acute Wound Healing: The Biology of Acute Wound Failure. Surg Clin NA, 83, 463-481.
2. Halsted, W. S. (1887). Circular Suture of the Intestine - An Experimental Study. Am J Med Sci, 436-461.
3. “William Stewart Halsted: his life and contributions to surgery” Osborne, P. Lancet Oncol 2007; 8: 256–65
4. “William Stewart Halsted: Surgical pioneer” Burress, P Endoc Today (2010), 8: (2) 22
5. “William Stewart Halsted (1852–1922) Neurological stamp” Haas, LF J Neurol Neurosurg Psych 2000;69:641
Original image courtesy of "Images from the History of Medicine" at  www.nih.gov


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Homeostasis

Homeostasis is the coordinated set of physiological mechanisms that preserve a stable internal bodily environment (through feedback-controlled regulatory processes) despite fluctuations in the external environment. The concept applies to many dynamic regulations of physiological variables such as body temperature, pH, electrolyte balance, osmolarity, blood glucose, etc.

Claude Bernard (1813–1878) introduced the concept of a “milieu intérieur” the “internal environment” in 1865 where he stated “La fixité du milieu intérieur est la condition de la vie libre et indépendante.” (The constancy of the internal environment is the condition for a free and independent life). Walter B. Cannon (1871–1945) formally coined the term homeostasis in 1929. In his reasoning to name these processes under one name he used the Greek term "ομοιόσταση" [omeóstasí) meaning "constant & stable" or "similar & standing still" referring to a constant (internal) environment.

Disruption of homeostatic processes can contribute to disease states such as diabetes mellitus (failure of glucose homeostasis), heart failure (impaired circulatory stability), heat stroke and/or hypothermia (thermoregulatory failure), hyponatremia or hypernatremia (electrolyte imbalance), etc.

For additional information here is an article from the National Library of Medicine.

Sources
1. Claude Bernard, "Introduction à l’étude de la médecine expérimentale" (1865). 
2. “Organization for physiological homeostasis” Cannon W. B.; Physiol Rev. 1929; 9:399–431.
3. "Textbook of Medical Physiology"; Guyton, Arthur C and Hall, John E ISBN: 0721659446 USA: W.B. Saunders, 1996.
4. “Homeostasis and Body Fluid Regulation: An End Note”. De Luca LA Jr, David RB, Menani JV. Neurobiology of Body Fluid Homeostasis: Transduction and Integration. Boca Raton (FL): CRC Press/Taylor & Francis; 2014. Chapter 15