Medical Terminology Daily - Est. 2012

Medical Terminology Daily (MTD) is a blog sponsored by Clinical Anatomy Associates, Inc. as a service to the medical community. We post anatomical, medical or surgical terms, their meaning and usage, as well as biographical notes on anatomists, surgeons, and researchers through the ages. Be warned that some of the images used depict human anatomical specimens.

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A Moment in History

Georg Eduard Von Rindfleisch

Georg Eduard Von Rindfleisch
(1836 – 1908)

German pathologist and histologist of Bavarian nobility ancestry. Rindfleisch studied medicine in Würzburg, Berlin, and Heidelberg, earning his MD in 1859 with the thesis “De Vasorum Genesi” (on the generation of vessels) under the tutelage of Rudolf Virchow (1821 - 1902). He then continued as a assistant to Virchow in a newly founded institute in Berlin. He then moved to Breslau in 1861 as an assistant to Rudolf Heidenhain (1834–1897), becoming a professor of pathological anatomy. In 1865 he became full professor in Bonn and in 1874 in Würzburg, where a new pathological institute was built according to his design (completed in 1878), where he worked until his retirement in 1906.

He was the first to describe the inflammatory background of multiple sclerosis in 1863, when he noted that demyelinated lesions have in their center small vessels that are surrounded by a leukocyte inflammatory infiltrate.

After extensive investigations, he suspected an infectious origin of tuberculosis - even before Robert Koch's detection of the tuberculosis bacillus in 1892. Rindfleisch 's special achievement is the description of the morphologically conspicuous macrophages in typhoid inflammation. His distinction between myocardial infarction and myocarditis in 1890 is also of lasting importance.

Associated eponyms

"Rindfleisch's folds": Usually a single semilunar fold of the serous surface of the pericardium around the origin of the aorta. Also known as the plica semilunaris aortæ.

"Rindfleisch's cells": Historical (and obsolete) name for eosinophilic leukocytes.

Personal note: G. Rindfleisch’s book “Traité D' Histologie Pathologique” 2nd edition (1873) is now part of my library. This book was translated from German to French by Dr. Frédéric Gross (1844-1927) , Associate Professor of the Medicine Faculty in Nancy, France. The book is dedicated to Dr. Theodore Billroth (1829-1894), an important surgeon whose pioneering work on subtotal gastrectomies paved the way for today’s robotic bariatric surgery. Dr. Miranda.

Sources:
1. "Stedmans Medical Eponyms" Forbis, P.; Bartolucci, SL; 1998 Williams and Wilkins
2. "Rindfleisch, Georg Eduard von (bayerischer Adel?)" Deutsche Biographie
3. "The pathology of multiple sclerosis and its evolution" Lassmann H. (1999)  Philos Trans R Soc Lond B Biol Sci. 354 (1390): 1635–40.
4. “Traité D' Histologie Pathologique” G.E.
Rindfleisch 2nd Ed (1873) Ballieres et Fils. Paris, Translated by F Gross


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This article is part of the series "A Moment in History" where we honor those who have contributed to the growth of medical knowledge in the areas of anatomy, medicine, surgery, and medical research.

In 2013 I wrote a short biography of Dr. Ephraim McDowell (1771- 1830) for the sidebar on this blog entitled “A Moment in History”. While researching the life of this illustrious surgeon I learned that his house is now a National Historic Landmark and has been transformed into a museum in the city of Danville, Kentucky. It took me almost four years but on Sunday February 19, 2017 I was able to go visit this place. Following is a series of articles and pictures of this visit.

The house itself was built in the 1790’s and most of it has been restored and lovingly maintained by the city, the Kentucky Medical Association, a Board of Directors, and a group of volunteers that work as docents giving tours of the house.

Ephraim McDowell House and MuseumThe Ephraim McDowell House and Museum

Visiting the Ephraim McDowell House and Museum Dr. Miranda in front of the Ephraim McDowell House

The following is an edited excerpt of Wikipedia on the McDowell House:

“After McDowell's death in 1830 the house was sold. It was the home of a Centre College president for a short time. Later the entire area became a slum and tenement property. The house deteriorated badly. Dr. August Schachner, of Louisville, led the efforts to buy the house for restoration. In 1921 he visited the house. "Since our last visit, the house has continued its downward course until it has reached a point where it now seems almost beyond redemption”. The room in the rear of the corresponding front room on the second floor,"(the operating room) "which is on a lower level by several feet, is used as a dump for the ashes from the grates of the rooms on the second floor."

The Kentucky Medical Association bought the house in 1935 and deeded it to the state of Kentucky, who had it restored by the Works Progress Administration (WPA). It was dedicated on May 20, 1939. In 1948, Kentucky returned the property to the Kentucky Medical Association.

The Kentucky Pharmaceutical Society restored the Apothecary Shop in the late 1950s with help from the Eli Lily Foundation. It was furnished by the Pfizer Laboratories. It was dedicated and presented to the Kentucky Medical Association on August 14, 1959.”

The house is located at 125 South Second Street, Danville, KY 40422. It is a white two-story wooden structure considered to be large for the time. To the right side stands a small one-story brick structure, the apothecary, where Dr. McDowell would provide medicine for his patients and others. To the left is the patio and garden where Dr. McDowell would grow medicinal plants for the apothecary. On the garden front there is a large two-sided plaque that reads:

Front of the plaque at the Ephraim McDowell House
Front of the plaque at the Ephraim McDowell House

“Home of Ephraim McDowell, the “father of modern surgery.” Here on December 25, 1809 McDowell performed the first successful abdominal operation when he took a 22-pound ovarian cysts from Jane Todd Crawford of Green Co. With no anesthesia, she sang hymns during the operation. Crawford recovered in 25 days and lived until 1842”

Back of the plaque at the Ephraim McDowell House and Museum
Back of the plaque at the Ephraim McDowell House

“Built in three stages. Brick ell, or single-story wing, built 1790s. McDowell purchased house in 1802 and added front clapboard section c.1804. Rear brick office and formal gardens added in 1820. House sold when McDowell dies in 1830. 1n 1930s, Ky. Med. Assoc. bought house; restored by WPA. House dedicated on May 20, 1939. Now a house museum”

This article continues here