Fenestration

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A Moment in History

Georg Eduard Von Rindfleisch
(1836 – 1908)

German pathologist and histologist of Bavarian nobility ancestry. Rindfleisch studied medicine in Würzburg, Berlin, and Heidelberg, earning his MD in 1859 with the thesis “De Vasorum Genesi” (on the generation of vessels) under the tutelage of Rudolf Virchow (1821 - 1902). He then continued as a assistant to Virchow in a newly founded institute in Berlin. He then moved to Breslau in 1861 as an assistant to Rudolf Heidenhain (1834–1897), becoming a professor of pathological anatomy. In 1865 he became full professor in Bonn and in 1874 in Würzburg, where a new pathological institute was built according to his design (completed in 1878), where he worked until his retirement in 1906.

He was the first to describe the inflammatory background of multiple sclerosis in 1863, when he noted that demyelinated lesions have in their center small vessels that are surrounded by a leukocyte inflammatory infiltrate.

After extensive investigations, he suspected an infectious origin of tuberculosis - even before Robert Koch's detection of the tuberculosis bacillus in 1892. Rindfleisch 's special achievement is the description of the morphologically conspicuous macrophages in typhoid inflammation. His distinction between myocardial infarction and myocarditis in 1890 is also of lasting importance.

Associated eponyms

"Rindfleisch's folds": Usually a single semilunar fold of the serous surface of the pericardium around the origin of the aorta. Also known as the plica semilunaris aortæ.

"Rindfleisch's cells": Historical (and obsolete) name for eosinophilic leukocytes.

Personal note: G. Rindfleisch’s book “Traité D' Histologie Pathologique” 2nd edition (1873) is now part of my library. This book was translated from German to French by Dr. Frédéric Gross (1844-1927) , Associate Professor of the Medicine Faculty in Nancy, France. The book is dedicated to Dr. Theodore Billroth (1829-1894), an important surgeon whose pioneering work on subtotal gastrectomies paved the way for today’s robotic bariatric surgery. Dr. Miranda.

Sources:
1. "Stedmans Medical Eponyms" Forbis, P.; Bartolucci, SL; 1998 Williams and Wilkins
2. "Rindfleisch, Georg Eduard von (bayerischer Adel?)" Deutsche Biographie
3. "The pathology of multiple sclerosis and its evolution" Lassmann H. (1999) Philos Trans R Soc Lond B Biol Sci. 354 (1390): 1635–40.
4. “Traité D' Histologie Pathologique” G.E.
Rindfleisch 2nd Ed (1873) Ballieres et Fils. Paris, Translated by F Gross

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Details: Written by: Efrain A. Miranda, Ph.D.; Published: May 06, 2015; Hits: 6028

UPDATED: The root term for this word comes from the Latin [fenestram] meaning "window". [Fenestration] is "the presence or the act of creating a window". As an example, the term is used to describe a small, round opening found in the medial wall of the tympanic cavity (middle ear), the [fenestra cochleae] or [fenestra rotunda] meaning "round window" (see image 1).

Image 1

Fenestrations (Normal and abnormal) in the cusps of the aortic valve

Image 2

Fenestrations can be found as natural occurrences in the body, as a result of an infection or destructive process or pathology, or they can be surgical procedures attempting to create a window, opening, or foramen. The cusps of all the heart valves can present normal fenestrations in the distal aspect of the cusp, beyond the coaptation or closure line. These become abnormal fenestrations when they occur below the coaptation line which may need to be repaired. Image 2 shows normal and abnormal fenestrations in the cusps of an aortic valve. Fenestrations in a valve cusp can be caused by endocarditis, among other causes.

Some surgical fenestrations that can be described are:

1. Fenestration of a tooth, allowing for drainage.

2. Pericardial fenestration, also known as a "pericardial window" to allow for drainage of excessive pericardial fluid (pericardial effusion).

3. Fenestration in a Fontan procedure, where a small opening or "window" is created to relieve excessive pressure in the venous circulation.

Word suggested by: J.Estrada

Original image #1courtesy of bartleby.com. Image#2 property of CAA, Inc.Artist: Dr. Miranda

Fenestration

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