Medical Terminology Daily - Est. 2012

Medical Terminology Daily (MTD) is a blog sponsored by Clinical Anatomy Associates, Inc. as a service to the medical community. We post anatomical, medical or surgical terms, their meaning and usage, as well as biographical notes on anatomists, surgeons, and researchers through the ages. Be warned that some of the images used depict human anatomical specimens.

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A Moment in History

Georg Eduard Von Rindfleisch

Georg Eduard Von Rindfleisch
(1836 – 1908)

German pathologist and histologist of Bavarian nobility ancestry. Rindfleisch studied medicine in Würzburg, Berlin, and Heidelberg, earning his MD in 1859 with the thesis “De Vasorum Genesi” (on the generation of vessels) under the tutelage of Rudolf Virchow (1821 - 1902). He then continued as a assistant to Virchow in a newly founded institute in Berlin. He then moved to Breslau in 1861 as an assistant to Rudolf Heidenhain (1834–1897), becoming a professor of pathological anatomy. In 1865 he became full professor in Bonn and in 1874 in Würzburg, where a new pathological institute was built according to his design (completed in 1878), where he worked until his retirement in 1906.

He was the first to describe the inflammatory background of multiple sclerosis in 1863, when he noted that demyelinated lesions have in their center small vessels that are surrounded by a leukocyte inflammatory infiltrate.

After extensive investigations, he suspected an infectious origin of tuberculosis - even before Robert Koch's detection of the tuberculosis bacillus in 1892. Rindfleisch 's special achievement is the description of the morphologically conspicuous macrophages in typhoid inflammation. His distinction between myocardial infarction and myocarditis in 1890 is also of lasting importance.

Associated eponyms

"Rindfleisch's folds": Usually a single semilunar fold of the serous surface of the pericardium around the origin of the aorta. Also known as the plica semilunaris aortæ.

"Rindfleisch's cells": Historical (and obsolete) name for eosinophilic leukocytes.

Personal note: G. Rindfleisch’s book “Traité D' Histologie Pathologique” 2nd edition (1873) is now part of my library. This book was translated from German to French by Dr. Frédéric Gross (1844-1927) , Associate Professor of the Medicine Faculty in Nancy, France. The book is dedicated to Dr. Theodore Billroth (1829-1894), an important surgeon whose pioneering work on subtotal gastrectomies paved the way for today’s robotic bariatric surgery. Dr. Miranda.

Sources:
1. "Stedmans Medical Eponyms" Forbis, P.; Bartolucci, SL; 1998 Williams and Wilkins
2. "Rindfleisch, Georg Eduard von (bayerischer Adel?)" Deutsche Biographie
3. "The pathology of multiple sclerosis and its evolution" Lassmann H. (1999)  Philos Trans R Soc Lond B Biol Sci. 354 (1390): 1635–40.
4. “Traité D' Histologie Pathologique” G.E.
Rindfleisch 2nd Ed (1873) Ballieres et Fils. Paris, Translated by F Gross


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This is a series of articles on depression published as a community service. The information in these articles follow our Privacy and Security Guidelines and cannot be construed as medical guidance. For additional information and counseling, consult with your physician or the appropriate health care professional of your choice. You can also find information on TMS here.

Depression
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UPDATED
: Everyone occasionally feels blue or sad. There are also those dreaded "winter blues". But these feelings are usually short-lived and pass within a couple of days, usually with no problems or persistent symptoms. Some people may even say that they are "depressed". Although this is true, that person is not clinically depressed.

When an individual has clinical depression, there are physical changes that happen within the brain which reflect in attitudes, mood, symptoms, and actions.

Clinical depression is a common but serious mental disorder that affects over 20 million people in the United States, many of which will never seek diagnosis or treatment. Patients present with depressed mood, loss of interest or pleasure, decreased energy, feelings of guilt or low self-worth, abnormal patterns of sleep or appetite, gruesome nightmares, and poor concentration. Moreover, depression may often come with symptoms of anxiety and varying complex presentations of bipolar disorder.

These problems can become chronic or recurrent and lead to substantial impairment in an individual’s ability to take care of his or her everyday responsibilities. At its worst, depression can lead to a patient's attempt on their life. Clinical Depression interferes with daily life and causes pain for both the individual, their families, and loved ones. Patients with depressive disorder often go from one job to another, cannot work, or eventually end in disability, being maintained by their family or loved ones.

Many people afflicted with Major Depressive Disorder (MDD) never seek treatment. This is specially true in males, where the World Health Organization (WHO) estimates that ”fewer than 25% of male sufferers worldwide will seek treatment because of the social stigma associated with mental disorders including depression.”

Properly and timely treated, even those with the most severe depression, can get better. Medications, psychotherapy, and electroconvulsive therapy (ECT) are the most common methods to treat depression. As patients move from one medication to the next level medication as well as augmentation medication, the annual cost for medication can be staggering, as well as the common, insidious, and problematic systemic side effects of both the drug therapy and ECT therapy.

The main objective of all treatments for MDD is to attain remission, but in many cases just reducing the symptoms of MDD and reducing the amount and types of medication used is enough to bring the patient back to a productive life and enhance the relationship with their families and loved ones.


Next article: Symptoms of Depression