Medical Terminology Daily - Est. 2012

Medical Terminology Daily (MTD) is a blog sponsored by Clinical Anatomy Associates, Inc. as a service to the medical community. We post anatomical, medical or surgical terms, their meaning and usage, as well as biographical notes on anatomists, surgeons, and researchers through the ages. Be warned that some of the images used depict human anatomical specimens.

You are welcome to submit questions and suggestions using our "Contact Us" form. The information on this blog follows the terms on our "Privacy and Security Statement" and cannot be construed as medical guidance or instructions for treatment.


We have 160 guests online


A Moment in History

Jean George Bachman

Jean George Bachmann
(1877 – 1959)

French physician–physiologist whose experimental work in the early twentieth century provided the first clear functional description of a preferential interatrial conduction pathway. This structure, eponymically named “Bachmann’s bundle”, plays a central role in normal atrial activation and in the pathophysiology of interatrial block and atrial arrhythmias.

As a young man, Bachmann served as a merchant sailor, crossing the Atlantic multiple times. He emigrated to the United States in 1902 and earned his medical degree at the top of his class from Jefferson Medical College in Philadelphia in 1907. He stayed at this Medical College as a demonstrator and physiologist. In 1910, he joined Emory University in Atlanta. Between 1917 -1918 he served as a medical officer in the US Army. He retired from Emory in 1947 and continued his private medical practice until his death in 1959.

On the personal side, Bachmann was a man of many talents: a polyglot, he was fluent in German, French, Spanish and English. He was a chef in his own right and occasionally worked as a chef in international hotels. In fact, he paid his tuition at Jefferson Medical College, working both as a chef and as a language tutor.

The intrinsic cardiac conduction system was a major focus of cardiovascular research in the late nineteenth and early twentieth centuries. The atrioventricular (AV) node was discovered and described by Sunao Tawara and Karl Albert Aschoff in 1906, and the sinoatrial node by Arthur Keith and Martin Flack in 1907.

While the connections that distribute the electrical impulse from the AV node to the ventricles were known through the works of Wilhelm His Jr, in 1893 and Jan Evangelista Purkinje in 1839, the mechanism by which electrical impulses spread between the atria remained uncertain.

In 1916 Bachmann published a paper titled “The Inter-Auricular Time Interval” in the American Journal of Physiology. Bachmann measured activation times between the right and left atria and demonstrated that interruption of a distinct anterior interatrial muscular band resulted in delayed left atrial activation. He concluded that this band constituted the principal route for rapid interatrial conduction.

Subsequent anatomical and electrophysiological studies confirmed the importance of the structure described by Bachmann, which came to bear his name. Bachmann’s bundle is now recognized as a key determinant of atrial activation patterns, and its dysfunction is associated with interatrial block, atrial fibrillation, and abnormal P-wave morphology. His work remains foundational in both basic cardiac anatomy and clinical electrophysiology.

Sources and references
1. Bachmann G. “The inter-auricular time interval”. Am J Physiol. 1916;41:309–320.
2. Hurst JW. “Profiles in Cardiology: Jean George Bachmann (1877–1959)”. Clin Cardiol. 1987;10:185–187.
3. Lemery R, Guiraudon G, Veinot JP. “Anatomic description of Bachmann’s bundle and its relation to the atrial septum”. Am J Cardiol. 2003;91:148–152.
4. "Remembering the canonical discoverers of the core components of the mammalian cardiac conduction system: Keith and Flack, Aschoff and Tawara, His, and Purkinje" Icilio Cavero and Henry Holzgrefe Advances in Physiology Education 2022 46:4, 549-579.
5. Knol WG, de Vos CB, Crijns HJGM, et al. “The Bachmann bundle and interatrial conduction” Heart Rhythm. 2019;16:127–133.
6. “Iatrogenic biatrial flutter. The role of the Bachmann’s bundle” Constán E.; García F., Linde, A.. Complejo Hospitalario de Jaén, Jaén. Spain
7. Keith A, Flack M. The form and nature of the muscular connections between the primary divisions of the vertebrate heart. J Anat Physiol 41: 172–189, 1907.


 "Clinical Anatomy Associates, Inc., and the contributors of "Medical Terminology Daily" wish to thank all individuals who donate their bodies and tissues for the advancement of education and research”.

Click here for more information


abebooks banner

bookplateink.com

 

 


Text from the presentation at the 2014 Vesalius Continuum Meeting in Zakyhnthos, Greece by Pavlos Plessas.

This article appeared originally on the blog of Fr. Panagiotis Capodistrias, a Zakynthian priest and poet, and a former schoolmate of Pavlos Plessas on September, 2014. Published here with permission from the author


Pavlos Plessas
Pavlos Plessas

 
The circumstances of Andreas Vesalius’ death in Zakynthos in 1564 may have been described in one of two differing accounts, originally written by three different men between the years 1565 and 1573, in five different texts. No additional information from people who may have been in possession of some facts is known to have survived.

In two of those texts the writer Petrus Bizarus claims that a travelling goldsmith found the great anatomist abandoned in a miserable hut on a deserted beach, dying from an unspecified illness (1). The unnamed goldsmith, in spite of strong opposition from the locals, buried him with his own hands in a plot of land he purchased for that purpose.

The veracity of Bizarus’ account appears doubtful due to its pervasive vagueness and the improbability of such treatment of an important nobleman by both, the Venetian authorities of Zakynthos and his own companions. More importantly it is incompatible with the testimonies of Christoph Fürer von Haimendorf (2)  and Giovanni Zuallardo (3) , who saw Vesalius’ tomb at the Franciscan monastery of Santa Maria delle Grazie, in 1565 and 1586 respectively. Their testimonies are also supported by that of Filippo Pigafetta (4). From their descriptions it is obvious that Vesalius was buried with some decorum and his grave was not dug simply to prevent the desecration of the body by wild animals.

The rival account is given in two letters of Johannes Metellus (5) , written in 1565, and another by Reinerus Solenander  a year later. Two more of Vesalius’ contemporaries, Carolus Clusius and Henricus Pantaleon provided shortened versions of this account that do not offer additional information and, hence, will not be discussed further. According to Metellus and Solenander Vesalius’ tomb was paid for by a fellow passenger, a Georgius Boucherus of Nuremberg, returning from Egypt. This account is not only compatible with the testimonies of those who saw Vesalius’ tomb but its credibility is enhanced by Metellus’ mention of a gravestone, put up by Boucherus, and Solenander’s statement that Vesalius was buried “next to a chapel or shrine close to the port of Zakynthos”. Santa Maria delle Grazie was the only Western church near the port at the time (7). 

Original slide from the 2014 presentation
Click for a larger image

In a rather unexpected way this account’s credibility is further strengthened by the astonishing events it describes. For if someone is to present a fabricated account it is natural to try and make it as believable as possible. Even if the aim is to impress or to shock, the disturbing inventions have to have plausible and uncomplicated explanations. Contrary to this we are told of a ship that was unable to reach land for forty days, of severe food and water shortages, the consequent outbreak of an illness that caused many deaths but strangely affected only the pilgrims, Vesalius becoming depressed and anxious – which in the belief of Metellus contributed to his illness – his pleading to the crew to not bury him at sea, and finally his death as soon as they reached land – a very sudden collapse by the city gate according to Metellus. It will be shown that this sequence of extraordinary events has a reasonable, quite likely even, and singular explanation.

Article continued here: Powerful indications that Vesalius died from scurvy (2)

Sources and author's comments:
1. Historia di Pietro Bizari della guerra fatta in Ungheria dall'invictissimo imperatore de'christiani contra quello de'Turchi, Lyons, 1568, p. 179; also in his Pannonicum bellum, Basel, 1573, p. 284.  
2.
Itinerarium Aegypti, Arabiae, Palaestinae, Syriae, aliarumque Regionum Orientalium, Nuremberg, 1621, p.2  
3. Il devotissimo Viaggio Di Gierusalemme, Rome, 1595, pp. 85 – 86.  
4. Theatro del Mondo di A. Ortelio: da lui poco inanzi la sua morte riveduto, e di tavole nuove et commenti adorno, et arricchito, con la vita dell' autore. Traslato in lingua Toscana dal Sigr F. Pigafetta, 1608/1612, background information to Map 217. Pigafetta, commenting almost two decades after his visit to Zakynthos in July 1586, mistakenly named the burial place of Vesalius as the monastery of St Francis. However, he leaves no doubt with regards to which monastery he actually meant by corroborating Zuallardo’s story of the inscription’s looting by the Turks in 1571. There was indeed a St Francis monastery in Zakynthos. It was, however, inside the castle and, hence, it was never looted by the Turks. Santa Maria delle Grazie on the other hand was in the area that is known to have been looted. I am grateful to Marcel van den Broecke for sending me photographs of the original text kept in the Koninklijke Bibliotheek in Hague.  
5. Metellus’ letter to Georgius Cassander was published in Petrus Bertius’ Illustrium & clarorum Virorum EPISTOLAE SELECTIORES, Superiore saeculo scriptae vel a Belgis, vel ad Belgas, Leyden 1617, pp. 372 – 373. His short letter to Arnoldus Birckmannus is unpublished though an English translation is in Charles Donald O'Malley’s Andreas Vesalius of Brussels, 1514-1564. A photocopy was kindly provided by the Cushing/Whitney Medical Historical Library of Yale University and a transcript made by Maurits Biesbrouck.
6. Maurits Biesbrouck, Theodoor Goddeeris and Omer Steeno, The Last Months of Andreas Vesalius: a Coda, Vesalius – Acta Internationalia Historiae Medicinae, Vol. XVIII, No 2, December 2012, pp. 70 – 71, from Thomas Theodor Crusius’ Vergnügung müssiger Stunden,oder allerhand nutzliche zur heutigen galanten Gelehrsamkeit dienende Anmerckungen of 1722. 
7. The monastery of St Elias was on the hill high above the port and St Franciscus even higher, inside the castle. St Mark was built later, in the 17th century.