Medical Terminology Daily - Est. 2012

Medical Terminology Daily (MTD) is a blog sponsored by Clinical Anatomy Associates, Inc. as a service to the medical community. We post anatomical, medical or surgical terms, their meaning and usage, as well as biographical notes on anatomists, surgeons, and researchers through the ages. Be warned that some of the images used depict human anatomical specimens.

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A Moment in History

Georg Eduard Von Rindfleisch

Georg Eduard Von Rindfleisch
(1836 – 1908)

German pathologist and histologist of Bavarian nobility ancestry. Rindfleisch studied medicine in Würzburg, Berlin, and Heidelberg, earning his MD in 1859 with the thesis “De Vasorum Genesi” (on the generation of vessels) under the tutelage of Rudolf Virchow (1821 - 1902). He then continued as a assistant to Virchow in a newly founded institute in Berlin. He then moved to Breslau in 1861 as an assistant to Rudolf Heidenhain (1834–1897), becoming a professor of pathological anatomy. In 1865 he became full professor in Bonn and in 1874 in Würzburg, where a new pathological institute was built according to his design (completed in 1878), where he worked until his retirement in 1906.

He was the first to describe the inflammatory background of multiple sclerosis in 1863, when he noted that demyelinated lesions have in their center small vessels that are surrounded by a leukocyte inflammatory infiltrate.

After extensive investigations, he suspected an infectious origin of tuberculosis - even before Robert Koch's detection of the tuberculosis bacillus in 1892. Rindfleisch 's special achievement is the description of the morphologically conspicuous macrophages in typhoid inflammation. His distinction between myocardial infarction and myocarditis in 1890 is also of lasting importance.

Associated eponyms

"Rindfleisch's folds": Usually a single semilunar fold of the serous surface of the pericardium around the origin of the aorta. Also known as the plica semilunaris aortæ.

"Rindfleisch's cells": Historical (and obsolete) name for eosinophilic leukocytes.

Personal note: G. Rindfleisch’s book “Traité D' Histologie Pathologique” 2nd edition (1873) is now part of my library. This book was translated from German to French by Dr. Frédéric Gross (1844-1927) , Associate Professor of the Medicine Faculty in Nancy, France. The book is dedicated to Dr. Theodore Billroth (1829-1894), an important surgeon whose pioneering work on subtotal gastrectomies paved the way for today’s robotic bariatric surgery. Dr. Miranda.

Sources:
1. "Stedmans Medical Eponyms" Forbis, P.; Bartolucci, SL; 1998 Williams and Wilkins
2. "Rindfleisch, Georg Eduard von (bayerischer Adel?)" Deutsche Biographie
3. "The pathology of multiple sclerosis and its evolution" Lassmann H. (1999)  Philos Trans R Soc Lond B Biol Sci. 354 (1390): 1635–40.
4. “Traité D' Histologie Pathologique” G.E.
Rindfleisch 2nd Ed (1873) Ballieres et Fils. Paris, Translated by F Gross


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Lithopedion Clark,JG 1897
Lithopedion Clark,JG 1897


This word originates from the root terms [-lith-], which arises from the Greek word [λίθος] meaning “stone” and the term [-pedion-] (or [pædion]) which is also Greek [παιδί] meaning “child”. In simple terms this would mean a “stone child”.

Strangely enough, “stone children” or lithopædia are rare cases found in nature, and have been described in humans since early times, the first one by Abū al-Qāsim (Abulcasis) in the 10th century.

When found, it is usually a fetus of more than 12 weeks of estimated age. This is because a younger fetus, if it dies, will usually be reabsorbed by the mother’s body. Usually they are ectopic pregnancies where the fetus dies and is calcified, turning into “stone”.

Technically there are three types of lithopaedia:

1. Lithokelyphos: Only the surrounding fetal membranes calcify. The fetus decomposes and is absorbed, while the calcified membranes protect the mother from the effects of necrosis.

2. Lithokelyphopaedion: Where the membranes and the fetus calcify.

3. True lithopedion, also known as “lithopedion proper”, or lithotecnon. The most common presentation when found, only the fetus is calcified.

The incidence of lithopedia is estimated close to 1.8% of ectopic pregnancies. The following images are of a lithopedion case described by Bainbridge in 1911 and include an X-Ray of the lithopedion.

Lithopedion. Bainbridge, WS 1911
Lithopedion 
Click for a larger image

Lithopedion. Bainbridge, WS 1911
Lithopedion 
Click for a larger image

Sources:
1. “A rare case of Lithopedion” Clark, JG John Hopkins Hospital Bulletin Volume 8 (1897) 221-228
2. “Lithopedion, Report of a case with a review of the literature” Bainbridge, WS. Am J Obstr V65 (1911) 31 – 52
3. “Chilean woman carried calcified foetus for 50 years” BBC News
4. Blog: James Edwards Hughes “The Lithopedion”