Medical Terminology Daily - Est. 2012

Medical Terminology Daily (MTD) is a blog sponsored by Clinical Anatomy Associates, Inc. as a service to the medical community. We post anatomical, medical or surgical terms, their meaning and usage, as well as biographical notes on anatomists, surgeons, and researchers through the ages. Be warned that some of the images used depict human anatomical specimens.

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A Moment in History

Georg Eduard Von Rindfleisch

Georg Eduard Von Rindfleisch
(1836 – 1908)

German pathologist and histologist of Bavarian nobility ancestry. Rindfleisch studied medicine in Würzburg, Berlin, and Heidelberg, earning his MD in 1859 with the thesis “De Vasorum Genesi” (on the generation of vessels) under the tutelage of Rudolf Virchow (1821 - 1902). He then continued as a assistant to Virchow in a newly founded institute in Berlin. He then moved to Breslau in 1861 as an assistant to Rudolf Heidenhain (1834–1897), becoming a professor of pathological anatomy. In 1865 he became full professor in Bonn and in 1874 in Würzburg, where a new pathological institute was built according to his design (completed in 1878), where he worked until his retirement in 1906.

He was the first to describe the inflammatory background of multiple sclerosis in 1863, when he noted that demyelinated lesions have in their center small vessels that are surrounded by a leukocyte inflammatory infiltrate.

After extensive investigations, he suspected an infectious origin of tuberculosis - even before Robert Koch's detection of the tuberculosis bacillus in 1892. Rindfleisch 's special achievement is the description of the morphologically conspicuous macrophages in typhoid inflammation. His distinction between myocardial infarction and myocarditis in 1890 is also of lasting importance.

Associated eponyms

"Rindfleisch's folds": Usually a single semilunar fold of the serous surface of the pericardium around the origin of the aorta. Also known as the plica semilunaris aortæ.

"Rindfleisch's cells": Historical (and obsolete) name for eosinophilic leukocytes.

Personal note: G. Rindfleisch’s book “Traité D' Histologie Pathologique” 2nd edition (1873) is now part of my library. This book was translated from German to French by Dr. Frédéric Gross (1844-1927) , Associate Professor of the Medicine Faculty in Nancy, France. The book is dedicated to Dr. Theodore Billroth (1829-1894), an important surgeon whose pioneering work on subtotal gastrectomies paved the way for today’s robotic bariatric surgery. Dr. Miranda.

Sources:
1. "Stedmans Medical Eponyms" Forbis, P.; Bartolucci, SL; 1998 Williams and Wilkins
2. "Rindfleisch, Georg Eduard von (bayerischer Adel?)" Deutsche Biographie
3. "The pathology of multiple sclerosis and its evolution" Lassmann H. (1999)  Philos Trans R Soc Lond B Biol Sci. 354 (1390): 1635–40.
4. “Traité D' Histologie Pathologique” G.E.
Rindfleisch 2nd Ed (1873) Ballieres et Fils. Paris, Translated by F Gross


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This article is part of the series "A Moment in History" where we honor those who have contributed to the growth of medical knowledge in the areas of anatomy, medicine, surgery, and medical research.

Lorenz Heister
Lorenz Heister

Lorenz Heister (1683-1758) A German surgeon, physician, anatomist, and botanist, Lorenz Heister [also known as Laurentius Heisterus] was born at Frankfurt-am-Main in 1683. As a result of his early studies, he became proficient in Latin, French, English and Dutch. He started medical studies at the University of Giessen, later continuing in Amsterdam, and Leyden, where he obtained his MD degree in 1708.

For a short time Heister became an army surgeon. In 1710 he was appointed Professor of Anatomy and Surgery at the University of Altfdorf. Although he lectured in Latin, Heister published his anatomical treatise “Compendium Anatomicum” in German in 1718. Later, Latin, French, Italian, and Spanish translations were created and published. Heister’s book became the main anatomical and surgical textbook in Europe. The English version was first published in 1743.

Heister is considered the “Father of German Surgery”, including in his books the management of hemorrhage, wounds, fractures, bandaging, instrumentation, and surgery. Heister described the surgical treatment of breast cancer, hemothoraces, spinal fractures, trepanation, oral surgery, and even obstetrical emergencies. He introduced the term “tracheotomy.” Heister also studied the eye, confirming that cataracts are formed within the lens.

His name is remembered eponymically in two structures:

  • Heister’s valve (plica spiralis) a spiral fold of mucosa found in the cystic duct
  • Heister’s diverticulum (bulbus superius venae jugularis interna), a dilation of the internal jugular vein found at its origin from the jugular foramen of the base of the cranium

Heister's name is spelled Heisters, in his "Compendium Anatomicum" published in 1756.

Sources:
1. "Heister of the spiral valve of Heister - Lorenz Heister" Gastroenter Hepat News (2006): 131 (3) 696. 
2. “Lorenz Heister: Surgeon (1683-1758)” Stewart, J. Can Med Assoc J. 1929 20(4): 418–419. 
3. "Lorenz Heister (1683-1758). Eighteenth century surgeon" JAMA 202 (11), 1048-1049
4. "Lorenz Heister and oral disease with the original text from his papers". Shklar , G. J Hist Dent (2007); 55:2 68-74