Medical Terminology Daily - Est. 2012

Medical Terminology Daily (MTD) is a blog sponsored by Clinical Anatomy Associates, Inc. as a service to the medical community. We post anatomical, medical or surgical terms, their meaning and usage, as well as biographical notes on anatomists, surgeons, and researchers through the ages. Be warned that some of the images used depict human anatomical specimens.

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A Moment in History

Georg Eduard Von Rindfleisch

Georg Eduard Von Rindfleisch
(1836 – 1908)

German pathologist and histologist of Bavarian nobility ancestry. Rindfleisch studied medicine in Würzburg, Berlin, and Heidelberg, earning his MD in 1859 with the thesis “De Vasorum Genesi” (on the generation of vessels) under the tutelage of Rudolf Virchow (1821 - 1902). He then continued as a assistant to Virchow in a newly founded institute in Berlin. He then moved to Breslau in 1861 as an assistant to Rudolf Heidenhain (1834–1897), becoming a professor of pathological anatomy. In 1865 he became full professor in Bonn and in 1874 in Würzburg, where a new pathological institute was built according to his design (completed in 1878), where he worked until his retirement in 1906.

He was the first to describe the inflammatory background of multiple sclerosis in 1863, when he noted that demyelinated lesions have in their center small vessels that are surrounded by a leukocyte inflammatory infiltrate.

After extensive investigations, he suspected an infectious origin of tuberculosis - even before Robert Koch's detection of the tuberculosis bacillus in 1892. Rindfleisch 's special achievement is the description of the morphologically conspicuous macrophages in typhoid inflammation. His distinction between myocardial infarction and myocarditis in 1890 is also of lasting importance.

Associated eponyms

"Rindfleisch's folds": Usually a single semilunar fold of the serous surface of the pericardium around the origin of the aorta. Also known as the plica semilunaris aortæ.

"Rindfleisch's cells": Historical (and obsolete) name for eosinophilic leukocytes.

Personal note: G. Rindfleisch’s book “Traité D' Histologie Pathologique” 2nd edition (1873) is now part of my library. This book was translated from German to French by Dr. Frédéric Gross (1844-1927) , Associate Professor of the Medicine Faculty in Nancy, France. The book is dedicated to Dr. Theodore Billroth (1829-1894), an important surgeon whose pioneering work on subtotal gastrectomies paved the way for today’s robotic bariatric surgery. Dr. Miranda.

Sources:
1. "Stedmans Medical Eponyms" Forbis, P.; Bartolucci, SL; 1998 Williams and Wilkins
2. "Rindfleisch, Georg Eduard von (bayerischer Adel?)" Deutsche Biographie
3. "The pathology of multiple sclerosis and its evolution" Lassmann H. (1999)  Philos Trans R Soc Lond B Biol Sci. 354 (1390): 1635–40.
4. “Traité D' Histologie Pathologique” G.E.
Rindfleisch 2nd Ed (1873) Ballieres et Fils. Paris, Translated by F Gross


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Hyaline cartilage. Image courtesy of Dr. Stephen Gallik
Hyaline cartilage


Cartilage is a type of avascular tissue with a highly specialized extracellular matrix that contains chondrocytes.  The condrocytes produce and maintain the extracellular matrix. The root term meaning [cartilage] is  [-chondr-], which originatesfrom the Greek [χόνδρος] or [chondros] meaning "cartilage" or "gristle". The Latin equivalent is [cartilago] giving us the synonymous root term [-cartilag-], from which [cartilage] arises.

The matrix contains large amounts of glicosaminoglycans, which allows for easy diffusion of substances from surrounding structures and blood vessels. Being avascular, cartilage does not have its own blood supply. The extracellular matrix also has large quantities of hyaluronic acid, which allows cartilage a weight-bearing capacity. This is why cartilage is particularly useful in bony joints and covering articular surfaces.

There are three types of cartilage present in the human body:

• Elastic cartilage: This type of cartilage is characterized by elastic fibers, usually in layers or lamellae

• Fibrocartilage: This type of cartilage is characterized by large bundles of collagen, making it look and feel fibrous

Hyaline cartilage: This type of cartilage is characterized by an homogenous amorphous matrix

Thanks to Dr. Stephen Gallik for the mage and links. For more information on mammalian hystology, you can visit Dr. Gallik's website here.