Medical Terminology Daily - Est. 2012

Medical Terminology Daily (MTD) is a blog sponsored by Clinical Anatomy Associates, Inc. as a service to the medical community. We post anatomical, medical or surgical terms, their meaning and usage, as well as biographical notes on anatomists, surgeons, and researchers through the ages. Be warned that some of the images used depict human anatomical specimens.

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A Moment in History

Georg Eduard Von Rindfleisch

Georg Eduard Von Rindfleisch
(1836 – 1908)

German pathologist and histologist of Bavarian nobility ancestry. Rindfleisch studied medicine in Würzburg, Berlin, and Heidelberg, earning his MD in 1859 with the thesis “De Vasorum Genesi” (on the generation of vessels) under the tutelage of Rudolf Virchow (1821 - 1902). He then continued as a assistant to Virchow in a newly founded institute in Berlin. He then moved to Breslau in 1861 as an assistant to Rudolf Heidenhain (1834–1897), becoming a professor of pathological anatomy. In 1865 he became full professor in Bonn and in 1874 in Würzburg, where a new pathological institute was built according to his design (completed in 1878), where he worked until his retirement in 1906.

He was the first to describe the inflammatory background of multiple sclerosis in 1863, when he noted that demyelinated lesions have in their center small vessels that are surrounded by a leukocyte inflammatory infiltrate.

After extensive investigations, he suspected an infectious origin of tuberculosis - even before Robert Koch's detection of the tuberculosis bacillus in 1892. Rindfleisch 's special achievement is the description of the morphologically conspicuous macrophages in typhoid inflammation. His distinction between myocardial infarction and myocarditis in 1890 is also of lasting importance.

Associated eponyms

"Rindfleisch's folds": Usually a single semilunar fold of the serous surface of the pericardium around the origin of the aorta. Also known as the plica semilunaris aortæ.

"Rindfleisch's cells": Historical (and obsolete) name for eosinophilic leukocytes.

Personal note: G. Rindfleisch’s book “Traité D' Histologie Pathologique” 2nd edition (1873) is now part of my library. This book was translated from German to French by Dr. Frédéric Gross (1844-1927) , Associate Professor of the Medicine Faculty in Nancy, France. The book is dedicated to Dr. Theodore Billroth (1829-1894), an important surgeon whose pioneering work on subtotal gastrectomies paved the way for today’s robotic bariatric surgery. Dr. Miranda.

Sources:
1. "Stedmans Medical Eponyms" Forbis, P.; Bartolucci, SL; 1998 Williams and Wilkins
2. "Rindfleisch, Georg Eduard von (bayerischer Adel?)" Deutsche Biographie
3. "The pathology of multiple sclerosis and its evolution" Lassmann H. (1999)  Philos Trans R Soc Lond B Biol Sci. 354 (1390): 1635–40.
4. “Traité D' Histologie Pathologique” G.E.
Rindfleisch 2nd Ed (1873) Ballieres et Fils. Paris, Translated by F Gross


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This article is part of the series "A Moment in History" where we honor those who have contributed to the growth of medical knowledge in the areas of anatomy, medicine, surgery, and medical research.

This is the continuation of the article “The Ephraim McDowell House and Museum (3)”. For the first article, click here.

The rest of the house is interesting. The kitchen is an open hearth typical of the times and beneath the operating room. Candle molds, butter churners, baking tables, iron cooking utensils, etc. The guide explained that most of the cooking work was done by slaves.

To the back of the house if a large garden. Part of it is shaped as a Maltese cross, and this is where Dr. McDowell cultivated medicinal plants and herbs for his practice and the apothecary, The garden has several monuments, one of which is the original slab that covered Dr. McDowell's tomb.

The kitchen
The kitchen 

The back of the house
The back of the house

The apothecary

This "pharmacy" of the times is incredibly well-preserved, maintained and furnished. It is said that Dr. McDowell worked so much at this place that he eventually moved to the country to a second house he named "Cambiskenneth" after a famous local native american chief.

The apothecary has a basement that is off-limits to visitors, but there are photographs of the location for visitors to see.

Some of the porcelain and glass containers still have some of their contents.

The apothecary
The apothecary

The apothecary
The apothecary

Additional historic buildings

Just across from the McDowell House and Museum is the Constitution Square, a site that I would encourage you to visit. Following is an excerpt of the Danville KY website on the Constitution Square Historic Site:

"This is the birthplace of Kentucky's statehood. In 1776, Kentucky was still part of the frontier and a county of Virginia. The Wilderness Road, blazed by Daniel Boone, led pioneers through the Cumberland Gap and into Central Kentucky. Danville's prominent location on the Wilderness Road caused it to become a crossroad for early settlers, and a center of political activity.

By 1785, Danville was chosen as Kentucky's first seat of government, and a meetinghouse, courthouse and jail were built to administer the growing territory. Still bound to Virginia laws, though, several Danville citizens formed the political club that recognized the need for a convention to discuss statehood. Between 1784-1792, ten constitutional conventions took place at the courthouse of Constitution Square. In 1790, Kentucky delegates accepted Virginia's terms for separation from the state. On June 1, 1792, Kentucky became the fifteenth state in the union, and Isaac Shelby, a Revolutionary War hero, was named the first Governor of the Commonwealth."

Several original buildings and replicas are found at this site.

In closing this series of articles I can only say that this was an interesting personal and learning experience. Being able to visit The Ephraim McDowell House and Museum allowed me to envision the life of this time. To place it in perspective the year that Dr. McDowell operated on Mrs. Crawford was 1809. On the same year Abraham Lincoln was born  (only 35 miles from the farm of Mrs. Crawford), James Madison was the 4th president of the United States of America (which had only 15 states and 6 territories), Napoleon occupied Vienna, and Ludwig van Beethoven had just finished writing his Fifth Symphony.

Following is a large image of the original house prior to its renovation. The image is in the public domain from a biographical book by Dr. McDowell's granddaughter Mary Young Ridenbaugh.

The old McDowell residence
Click on the image for a larger depiction 

Sources:
1. “Ephraim McDowell and Jane Todd Crawford, the Bicentennial of a Surgical Masterpiece” Benigno, BB Obst & Gynecol (2009) 113. 5:1141-1144
2. “The Biography of Ephraim McDowell, M.D.; The Father of Ovariotomy” Ridenbaugh, MY, 1890 CL Webster & Co.
3. “Ephraim McDowell: "Father of ovariotomy" and founder of abdominal surgery, with an appendix on Jane Todd Crawford” Schachner, A 1921, J.B. Lippincott Co. (Interesting discovery in an Ex-Libris in this book)