Medical Terminology Daily (MTD) is a blog sponsored by Clinical Anatomy Associates, Inc. as a service to the medical community. We post anatomical, medical or surgical terms, their meaning and usage, as well as biographical notes on anatomists, surgeons, and researchers through the ages. Be warned that some of the images used depict human anatomical specimens.

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A Moment in History

Larsen

William J. Larsen, PhD
(1942-2000)

An American scientist, Dr. Larsen was a gifted scientist, consistently producing research at the forefront of cell, developmental, and reproductive biology. Early in his career he published a landmark paper that conclusively established mitochondrial fission as the mechanism of mitochondrial biogenesis. He went on to become the first to demonstrate the endocytosis of gap junctions. Moreover, his work on the hormonal regulation of gap junction formation and growth culminated in an authoritative review article in Tissue and Cell, “Structural Diversity of Gap Junctions (1988)”, which became a citation classic.

Throughout his 25 year teaching career, his sixty-seven peer reviewed publications—not to mention numerous invited reviews, abstracts, and book chapters—covered a wide range of research areas including adrenal cortical tumor cells, human ovarian carcinomas, preterm labor, cumulus expansion, oocyte maturation, ovulation, folliculogenesis, and in-vitro fertilization.

In addition to his many contributions to basic research, Dr. Larsen loved to teach and was much appreciated by his students. His exceptional ability was reflected in the four teaching awards he received as a professor at the University of Cincinnati.

Notably, he was the author of Human Embryology, a textbook for medical students that was the first to incorporate modern experimental research into a subject that had traditionally been taught in a strictly descriptive style. On its initial publication in 1998 it was hailed as, “a magnificent book…” by the European Medical Journal. With the release of the fourth edition in 2008, the book was renamed “Larsen’s Human Embryology” in recognition of Dr. Larsen's place as the originator of this revolutionary text. This book is today in it's 6th Edition.

His stellar scientific career would be enough for most people, but Dr. Larsen pursued his numerous and varied interests with such extraordinary passion, energy, and skill that he seemed to have more hours in a day than the ordinary person. He was fascinated with the American Southwest and studied and collected traditional arts and crafts of the Hopi, Zuni, and Navajo peoples. He was a woodworker who built three harpsichords and a fortepiano for his wife, and, with his two children, over 100 pieces of gallery-quality furniture. In addition, he loved to regale his friends, colleagues, and students with jokes and stories, and to share his love for gourmet cooking.

The William J. Larsen Distinguished Lecture Series

An annual lecture series was created for the Department of Cancer & Cell Biology at the University of Cincinnati to honor Dr. Larsen's research which was at the forefront of cell developmental and reproductive biology. This series recognizes forward-thinking research scientists in the field of developmental biology and asks that they share their research and findings with students and faculty of the University of Cincinnati, College of Medicine.

Personal note: I had the opportunity to meet and attend Dr. Larsen’s embryology lectures as he and I worked in the Anatomy, Embryology, and Histology program at the University of Cincinnati Medical College. Unfortunately, I never had the opportunity to have Dr. Larsen sign my personal copy of his book. He is sorely missed, Dr. Miranda

Sources:

1. "The William J. Larsen Distinguished Lecture Series" University of Cincinnati, College of Medicine.
2. https://www.larsenbooks.com
3. 2022 Larsen Lecture Series brochure (download here)
4. Dr. Larsen's family personal communications


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Combining root terms

Most medical words have only one root term and do not require combination as in the word [colectomy]. The situation arises when there is more than one organ or structure that is influenced by the suffix and the prefix (when present), such as [coloproctectomy]. Following are the basic rules for root terms combination:

  1. - Place an [-o-] between the root terms being combined. The combining vowel  [o] means "and". The word [gastroenterology] means "study of the stomach and the small intestine"
  2. - Organize the root terms using their proximal to distal relationship. For a better explanation, click here
  3. - If the first root term ends in a vowel, the combining vowel [-o-] is not needed. An example are the root terms [-chole-], meaning "bile or gall". and [cyst], meaning "bladder or sac". The word [chole-cyst-ectomy] does not have an [-o-] between the root terms
  4. - If the proximal to distal relationship does not apply, then the words should be ordered in a way that is euphonic
  5. - The only time a hyphen should be used is the rare case when using an [o] is not possible. Based on this rule, the word [salpingooophorectomy] is correct, the word [salpingo-oophorectomy] is not. An example of this is the word [cross-section].

An example of rule #5 is the word co-author. Since adding an [o] as a combining vowel would give us the word cooauthor (which is not correct), a hyphen must be used.

In the case of the word [coloproctectomy] the word can be divided into these components" The first root term [-col-], meaning "colon", the combining vowel [-o-], meaning "and", the second root term [-proct-], meaning "rectum", and the suffix [-ectomy], meaning "removal of". Properly read, the word means "removal of colon and rectum]. The proper term is [coloproctectomy], please do not use the terms [proctocolectomy] or worse, [protocolectomy], because they are incorrect usage of medical terminology.

For information on how to read medical words, click here.

There are more nuances to Medical Terminology, but they go beyond the objectives of "Medical Terminology Daily". For a complete course on Medical Terminology for your company, contact CAA, Inc.

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