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Jean George Bachmann
(1877 – 1959)
French physician–physiologist whose experimental work in the early twentieth century provided the first clear functional description of a preferential interatrial conduction pathway. This structure, eponymically named “Bachmann’s bundle”, plays a central role in normal atrial activation and in the pathophysiology of interatrial block and atrial arrhythmias.
As a young man, Bachmann served as a merchant sailor, crossing the Atlantic multiple times. He emigrated to the United States in 1902 and earned his medical degree at the top of his class from Jefferson Medical College in Philadelphia in 1907. He stayed at this Medical College as a demonstrator and physiologist. In 1910, he joined Emory University in Atlanta. Between 1917 -1918 he served as a medical officer in the US Army. He retired from Emory in 1947 and continued his private medical practice until his death in 1959.
On the personal side, Bachmann was a man of many talents: a polyglot, he was fluent in German, French, Spanish and English. He was a chef in his own right and occasionally worked as a chef in international hotels. In fact, he paid his tuition at Jefferson Medical College, working both as a chef and as a language tutor.
The intrinsic cardiac conduction system was a major focus of cardiovascular research in the late nineteenth and early twentieth centuries. The atrioventricular (AV) node was discovered and described by Sunao Tawara and Karl Albert Aschoff in 1906, and the sinoatrial node by Arthur Keith and Martin Flack in 1907.
While the connections that distribute the electrical impulse from the AV node to the ventricles were known through the works of Wilhelm His Jr, in 1893 and Jan Evangelista Purkinje in 1839, the mechanism by which electrical impulses spread between the atria remained uncertain.
In 1916 Bachmann published a paper titled “The Inter-Auricular Time Interval” in the American Journal of Physiology. Bachmann measured activation times between the right and left atria and demonstrated that interruption of a distinct anterior interatrial muscular band resulted in delayed left atrial activation. He concluded that this band constituted the principal route for rapid interatrial conduction.
Subsequent anatomical and electrophysiological studies confirmed the importance of the structure described by Bachmann, which came to bear his name. Bachmann’s bundle is now recognized as a key determinant of atrial activation patterns, and its dysfunction is associated with interatrial block, atrial fibrillation, and abnormal P-wave morphology. His work remains foundational in both basic cardiac anatomy and clinical electrophysiology.
Sources and references
1. Bachmann G. “The inter-auricular time interval”. Am J Physiol. 1916;41:309–320.
2. Hurst JW. “Profiles in Cardiology: Jean George Bachmann (1877–1959)”. Clin Cardiol. 1987;10:185–187.
3. Lemery R, Guiraudon G, Veinot JP. “Anatomic description of Bachmann’s bundle and its relation to the atrial septum”. Am J Cardiol. 2003;91:148–152.
4. "Remembering the canonical discoverers of the core components of the mammalian cardiac conduction system: Keith and Flack, Aschoff and Tawara, His, and Purkinje" Icilio Cavero and Henry Holzgrefe Advances in Physiology Education 2022 46:4, 549-579.
5. Knol WG, de Vos CB, Crijns HJGM, et al. “The Bachmann bundle and interatrial conduction” Heart Rhythm. 2019;16:127–133.
6. “Iatrogenic biatrial flutter. The role of the Bachmann’s bundle” Constán E.; García F., Linde, A.. Complejo Hospitalario de Jaén, Jaén. Spain
7. Keith A, Flack M. The form and nature of the muscular connections between the primary divisions of the vertebrate heart. J Anat Physiol 41: 172–189, 1907.
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Right homonymous superior quadrantanopia
[Quadrant]-[an-[opia ] The root “quadrant” is based on the Latin "Quadri" meaning "four" and “Quarto”, meaning one fourth. The suffix anopia is composite: “an” meaning “without or absence of”; and opia (or “opsia”) relate to vision, based on the Greek word “οπτασία” (optasía) meaning “sight”. Literally, the term quadrantanopia (or quadrantanopsia) means “absence of sight in a quadrant”.
It can be associated with a lesion of an optic radiation of the internal capsule. While quadrantanopia can be caused by lesions in the temporal and parietal lobes of the brain, it is most commonly associated with lesions in the occipital lobe.
What is interesting are the terms “homonymous” and “heteronymous” used to describe variants of quadrantanopia. Each eye has four quadrants and two visual fields, right and left. A homonymous quadrantanopia means that the patient has lost the vision of a quadrant in the same field in each eye (right-right or left-left), heteronymous means that the patient has lost the vision of a quadrant in the opposite field of each eye (right-left or left-right).
The fact is that the term homonymous means “same name” not same side, and the word heteronymous means “different name”, from the Greek “όνομα” “nym” meaning name. For further confirmation, try finding the meaning of synonym, antonym, acronym, patronymic, etc.
Sources:
1. "The Origin of Medical Terms" Skinner, HA 1970 Hafner Publishing Co.
2. "Medical Meanings - A Glossary of Word Origins" Haubrich, WD. ACP Philadelphia
3. "Dorlands's Illustrated Medical Dictionary" 26th Ed. W.B. Saunders 1994
Note: Google Translate includes an icon that will allow you to hear the pronunciation of the word
Image courtesy of Mudsk, CC0, via Wikimedia Commons.
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- Written by: Efrain A. Miranda, Ph.D.
- Hits: 1943
I had the honor of being invited to participate in the 53rd Annual Chilean Meeting of Anatomy (XLIII Congreso Chileno de Anatomía) which was held in conjunction with the 1st Latin American Congress of Clinical Morphology (Primer Congreso Latinoamericano de Morfología Clínica). Along with these meetings were two symposia: The First Joint Symposium of Chilean/Korean Anatomists and the First Joint Chilean - IFAA-FIPAE Symposium (International Federation of Associations of Anatomists - Federative International Program for Anatomy Education).
Universidad de Los Andes, Chile
This meeting was held on November 11- 14, 2023 and was hosted by the University of Los Andes (Universidad de Los Andes), a Chilean institution of private higher education that offers careers and postgraduate programs in different areas of knowledge including Education, Engineering, Nursing, Obstetrics, Medicine, Psychology, Law. etc. Their campus is located on the slopes of the beautiful Andes mountains overlooking the city of Santiago, Chile.
The image shows the Main Library of the University, where the meeting was held.
On November 9 and 10, the days leading to the meeting, there were six Postgraduate Courses, from anatomy to radiology and surgical reconstruction. There were two that I would like to highlight. The first one was a workshop "Mastering Anatomical Radiology with IMAIOS", where one of the instructors was my good friend Dr. Cristian Uribe, who was one of the Meeting organizers. Dr. Uribe is one of the contributors to Medical Terminology Daily.
The second one was a "Workshop on Art & Science: A Theoretical-Practical Course on Anatomical Illustration". This course was directed by my good friend, Dr. Carlos Machado, world-renown medical illustrator, physician, and anatomist, editor of Netter's Atlas of Anatomy. Along with him two professors, Drs. Daniel Casanova and Valentina Cerda.
Nov. 11, 2023 Meeting opening
The Meeting was officially opened by Dr. Juan Carlos Lopez, Director of the Morphology Department of the Los Andes University. This was followed by a presentation on "The Role of the Placenta on the Modulation of Human Potential" by Dr. Sebastian Illanes. On the picture, from left to right, Dr. Jens Wasche (Germany), Dra. Valentina Cerda (Chile), Dr. Carlos Machado (Brazil/USA), me (Chile/USA), and Dr. Andres Riveros Valdes (Chile), a good friend and anatomist. Dr. Riveros is the President of the LatinAmerican Meeting on Clinical Morphology.
There were so many great presentations in this meeting! I think the attendees will agree with me that the conference by Dr. Carlos Machado on "The Art of Learning and Teaching Anatomy with Art" was one of the highlights of the Meeting. In his presentation Dr. Machado shared some of his early drawings and his career in Medicine and Medical Illustration, how he has used art to show patient pathology, and most important, the work and dedication that is required when developing a single image that will later become part of the Anatomy Atlases with which he collaborates.
Dr. Carlos Machado
The image above shows Dr. Machado during his presentation. On the screen an anatomical image he drew when he was 12 year old!.
Dr. Carlos Machado
Dr. Cristian Uribe
Poster presentations during a coffee break
The meeting was also geared toward morphology students of different careers including Veterinary, Nursing, Dental School, and Medicine. The students presented their research posters during the coffee breaks. There were very high-quality and in-depth research, including the first osteology atlas of the Chilean flamingo (Phoenicopterus chilensis). I had interesting discussions on Latin terminology with these students.
There were extremely interesting topics throughout the week, including liver anatomy and liver transplant, ethics, philosophy, body donation, etc.
My presentation was based on the conference I delivered in May 2023 at the University of Antwerp, Belgium. Since the Belgium conference was delivered to a group of Andreas Vesalius experts, this one included much more information on Andreas Vesalius, his work, and additional information on printing techniques circa 1550.
Dr. Miranda during his presentation at the
XLIII Anatomy Meeting in Chile
The presentation added information on the history of the woodblocks used to print the 1543 Fabrica, the 1555 Fabrica, as well as other books that include the 1925 "The Iconography of Andreas Vesalius" by M.H. Spellman, and the 1934 Icones Anatomicæ.
The included picture was taken towards the end of my presentation where with the help of Dr. Uribe we unveiled Giovanni Paolo Mascagni's (1755-1815) work. At the center is a life-size copy of one of the pages of his book "Anatomiæ Universæ Icones", published in 9 installments between 1823 and 1832. It is important to note that each page of this book was hand-colored by Antonio Serantoni (1780-1837), thus the time it took to print and publish this book.
Mascagni's book, the largest book ever printed, shows in separate pages one third of a larger, life-size individual. Because of the rarity and value of this magnificent work, it cannot be cut and pasted.There are 16 know copies of Mascagni's anatomical opus magnus in the world, one of them at the University of Cincinnati, Ohio. USA.
With the help of Mr. Gino Pasi curator of the Henry Winkler Center for the History of the Health Professions, and the help of Mrs. Samantha Scheck, graphic designer, we measured and scanned some pages of the "Anatomiæ Universæ Icones", cleaned the background (no changes were done to the image itself) and pasted them digitally. The result is a life-size male 5.9 ft tall (1,75 mt). The images are incredible, and having traveled back and forth to Belgium and Chile, they are now part of my personal library.
Once again, my thanks to my old and new friends for making my stay so interesting, both personally and professionally. My thanks to the organizers of these meetings and symposia:
Dr. Juan Carlos López Navarro
President XLIII Chilean Anatomy Meeting
Director Morphology Department - Universidad de Los Andes
Dr. Andrés Riveros Valdés
President I Latin American Clinical Morphology Meeting
Professor - Universidad San Sebastián
Dra. Viviana Toro Ibacache
President Scientific Committee
Professor - Universidad de Chile
Dr. Emilio Farfán Cabello
President Chilean Anatomy Society
Professor - Pontificia Universidad Católica de Chile
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Chest X-Ray - dextrocardia
Normally, the heart is a midline structure found just posterior to the sternum where 35-40% of the heart mass in the right side of the thorax (chest), and the rest (60-65%) is in the left side of the thorax. In this normal condition the apex of the heart faces slightly inferior and to the left. In fact, there are many books and websites that state (wrongly) that the heart is normally in the “left side of the chest”.
If the above mentioned situation is reversed, we are in the presence of dextrocardia, that is, the heart is still in the midline, but most of the mass of the heart is in the right side of the thorax, and the apex points inferiorly and to the right.
The word dextrocardia is a derivate of the Latin [dexter], meaning “right”, and the Greek term [kardia], meaning “heart”. The word dextrocardia literally means “right-sided heart”.
Dextrocardia is a congenital condition, can be completely asymptomatic and present as an isolated condition. It can also be part of a complex genetic condition called “situs inversus” where the whole body is a mirror image of itself and all organs, including the heart are mirrored. A complete situs inversus is rare, but when present it usually does not cause problems.
The problems start when only part of the body and organs are reversed and others are not, causing an incredible number of potential anatomical variations and associated problems.
The prevalence of dextrocardia is about 1 in 12,00 pregnancies. The reported incidence is about 0.22%. Depending on the situation, dextrocardia can present with additional cardiac congenital disorders.
Sources:
1. “Dextrocardia: an incidental finding” Yusuf SW, Durand JB, Lenihan DJ, Swafford J. Tex Heart Inst J 2009;36(4):358-9.
2. Garg N, Agarwal BL, Modi N, Radhakrishnan S, Sinha N. Dextrocardia: an analysis of cardiac structures in 125 patients. Int J Cardiol 2003;88(2–3):143–56
3. Bernasconi A, Azancot A, Simpson JM, Jones A, Sharland GK. Fetal dextrocardia: diagnosis and outcome in two tertiary centres. Heart 2005;91(12):1590–4.
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- Written by: Efrain A. Miranda, Ph.D.
Sinus rhythm electrocardiogram
A contraction, from the Greek [συστολή] (systolí) meaning “contraction”, also [συστελλει] (systellei) meaning “to shrink, to shorten, or to draw together”.
It refers to the contraction of the heart. If you analyze a normal heartbeat (sinus rhythm), there are two systoles: an atrial systole, followed by a short interval, followed by the ventricular systole. The term systole is usually used in reference to the ventricular systole.
Systole was first recognized and named by Herophilus of Alexandria (325-255BC), most probably trough animal vivisection. Herophilus was accused of animal vivisection and the dissection of human cadavers. Because of this, some call Herophilus "The Father of Anatomy".
Galen of Pergamon (129AD - 200AD) used the term [συστελλεσθαι] meaning “contracted”.
The word in English was first used in the 16th century and was originally written as “sistole”, with an "i" instead of the accepted use today with a "y". The modern pronunciation in English follows the Greek pronunciation by ending the word in a long “e” as in “to be”.
Sources
1. "The Origin of Medical Terms" Skinner, HA 1970 Hafner Publishing Co.
2. "Medical Meanings - A Glossary of Word Origins" Haubrich, WD. ACP Philadelphia
3. "Dorlands's Illustrated Medical Dictionary" 26th Ed. W.B. Saunders 1994
4. "Greek anatomist Herophilus: the father of anatomy" Si-Yang, N. Anat Cell Biol. 2010; 43(4): 280–283
Note: Google Translate includes an icon that will allow you to hear the pronunciation of the word
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- Written by: Efrain A. Miranda, Ph.D.
Sinus rhythm electrocardiogram
Sinus Rhythm (SR), also known as Normal Sinus Rhythm (NSR) is the term used to denote normal cardiac activity. A normal beating heart is in sinus rhythm.
In the normal beating of the heart the left and right atria contract followed by the contraction of the left and right ventricles. These atrial and ventricular contractions are separated by a lag time of 1/10th of a second which allows the atria to relax (atrial diastole) while the ventricles contract (ventricular systole). The addition of the normal action of the four heart valves (tricuspid, mitral, aortic, and pulmonary) allows the heart to work as a blood pump and circulate blood within the heart and through the body and lungs.
SR is coordinated by a complex binary conduction system. The first part of the conduction system is composed of heart muscle cells (cardiomyocytes) which are characterized by automaticity. It is important to state here something that is known, but many times ignored: This portion of the conduction system is not composed of nerves... it is formed by specialized cardiac muscle cells! The description of this cardiomyocyte-based system can be read in a separate article here.
The second component of the conduction system is the cardiac autonomic nervous system (CANS), which acts as a moderator (accelerating or slowing) the cardiomyocyte-based conduction system. A separate article will be written soon and linked here. Suffice it to say (for now) that the CANS has two components, an extrinsic component formed by nerves and ganglia outside the heart, and an intrinsic component of nerves and ganglia that forms a complex network within the superficial aspect of the heart muscle and fat surrounding the heart. These are the ganglionated plexuses, and their dysfunction can cause abnormal heart rhythm.
When these two components and their thousands of cardiac muscle cells, ganglia, and nerves are working property, the heart is in sinus rhythm, and beats between 60 to a 100 times per minute.
Personal note: The term Normal Sinus Rhythm (NSR) is redundant. By definition, if the heart is in SR, it is normal. On the other hand, the term Abnormal Sinus Rhythm is also not correct… if the heartbeat is abnormal, the heart is not in SR! (Dr. Miranda)
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Histology image of cardiac muscle*
[UPDATED] Cardiac muscle is one of the three types of muscle found in the human body. It is found exclusively in the heart, where it forms the main component of its middle layer, the myocardium.
[Myo]=combining form for "muscle"; [-card-]=heart; and [-ium]=layer or membrane. The myocardium is the muscle layer of the heart.
Cardiac muscle has distinct striations and intercalated discs (see accompanying image). The cardiac muscle acts as a functional syncytium.
The key characteristic of cardiac muscle is automatism or automaticity, its capacity to contract rhythmically in the absence of an external electrical stimulus. The other two types of muscle (smooth and skeletal) lack this characteristic.
The term [cardiomyocyte] can be used to describe each of these cells as the word is composed of [Card(i)o=combining form for "heart"; [myo]=combining form for "muscle"; and the suffix [-cyte]= cell. A cardiomyocyte is a cardiac muscle cell.
One of the components of the conduction system of the heart is made exclusively of cardiomyocytes.
Image modified from the original on YouTube from the British Heart Foundation.
* Original histology image by S, Girod and A. Becker, courtesy of Wikipedia.