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Georg Eduard Von Rindfleisch
(1836 – 1908)
German pathologist and histologist of Bavarian nobility ancestry. Rindfleisch studied medicine in Würzburg, Berlin, and Heidelberg, earning his MD in 1859 with the thesis “De Vasorum Genesi” (on the generation of vessels) under the tutelage of Rudolf Virchow (1821 - 1902). He then continued as a assistant to Virchow in a newly founded institute in Berlin. He then moved to Breslau in 1861 as an assistant to Rudolf Heidenhain (1834–1897), becoming a professor of pathological anatomy. In 1865 he became full professor in Bonn and in 1874 in Würzburg, where a new pathological institute was built according to his design (completed in 1878), where he worked until his retirement in 1906.
He was the first to describe the inflammatory background of multiple sclerosis in 1863, when he noted that demyelinated lesions have in their center small vessels that are surrounded by a leukocyte inflammatory infiltrate.
After extensive investigations, he suspected an infectious origin of tuberculosis - even before Robert Koch's detection of the tuberculosis bacillus in 1892. Rindfleisch 's special achievement is the description of the morphologically conspicuous macrophages in typhoid inflammation. His distinction between myocardial infarction and myocarditis in 1890 is also of lasting importance.
Associated eponyms
"Rindfleisch's folds": Usually a single semilunar fold of the serous surface of the pericardium around the origin of the aorta. Also known as the plica semilunaris aortæ.
"Rindfleisch's cells": Historical (and obsolete) name for eosinophilic leukocytes.
Personal note: G. Rindfleisch’s book “Traité D' Histologie Pathologique” 2nd edition (1873) is now part of my library. This book was translated from German to French by Dr. Frédéric Gross (1844-1927) , Associate Professor of the Medicine Faculty in Nancy, France. The book is dedicated to Dr. Theodore Billroth (1829-1894), an important surgeon whose pioneering work on subtotal gastrectomies paved the way for today’s robotic bariatric surgery. Dr. Miranda.
Sources:
1. "Stedmans Medical Eponyms" Forbis, P.; Bartolucci, SL; 1998 Williams and Wilkins
2. "Rindfleisch, Georg Eduard von (bayerischer Adel?)" Deutsche Biographie
3. "The pathology of multiple sclerosis and its evolution" Lassmann H. (1999) Philos Trans R Soc Lond B Biol Sci. 354 (1390): 1635–40.
4. “Traité D' Histologie Pathologique” G.E.
Rindfleisch 2nd Ed (1873) Ballieres et Fils. Paris, Translated by F Gross
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This is the name given to a particular anatomical variation of the bifurcation of the left coronary artery (LMCA). Normally the LMCA bifurcates giving origin to the circumflex artery (CFX) and the anterior interventricular artery, also known as the left anterior descending artery (LAD).
In the case of the “ramus intermedius” variation, the LCMA trifurcates, that is, forks into three branches: an LAD, a CFX and an intermediate branch that provides blood supply to the anterolateral aspect of the left ventricular surface and/or the obtuse margin of the heart. The ramus intermedius may take one of two directions. It may behave like a diagonal branch (D1, D2) of the LAD or as an obtuse marginal artery (OM1).
The ramus intermedius anatomical variation is quite common and literature states that it may be present in 20-33% of the cases.
One of my pet peeves (see my top pet peeve here) is that most medical industry providers as well as many surgeons and physicians call this anatomical variation a “ramus”. You see, the Latin term [ramus] means “branch” and by itself is not descriptive. The proper name is the Latin term “ramus intermedius” which means “the intermediate branch”.
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The left coronary artery, sometimes called the [left main coronary artery] or LMCA, is a short artery that arises from the aortic root at the left posterior coronary sinus of Valsalva, usually below the sinotubular junction.
Its length is on average 1.3 cm, although it can be shorter. The LMCA courses between the left atrial appendage and the posterior aspect of the pulmonary trunk. The LMCA provides blood supply to almost 69% of the heart, making it most important in coronary blood supply to the heart. This apparently goes against the concept of coronary dominance if the concept is not clearly understood. You could have a "right dominant heart" and still have the LMCA provide blood supply to more than 50% of the heart.
The left coronary artery bifurcates giving origin to two branches: the circumflex artery (CFX) and the left anterior descending artery (LAD). Each one of these arteries gives origin to several named branches and you can click on the links to follow each one.
The left coronary artery has several anatomical variations, including one where it does not exist and the CFX and LAD arise separately from the aorta. In another common variation (25-33%) the aorta trifurcates giving rise to a [ramus intermedius]
Sources:
1 "Tratado de Anatomia Humana" Testut et Latarjet 8 Ed. 1931 Salvat Editores, Spain
2. "Gray's Anatomy" 38th British Ed. Churchill Livingstone 1995
3. “Anatomical variations in the left coronary artery and its branches” Hosapatna, M et al. Singapore Med J 2013; 54(1) : 49
4. "Quantitative study on the size of coronary artery supplying areas postmortem" Kalbfleisch H. Am Heart J 1977; 94:183-8.
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Anterior view of the heart
The obtuse marginal arteries are two (sometimes three) branches that arise of the circumflex artery and descend towards the cardiac apex with varying lengths. The first obtuse marginal artery (OM1) is usually found on or close to the obtuse margin of the heart, also known as the “margo obtusus”
The first obtuse marginal artery (OM1) along with the acute marginal artery are used to denote the lower portion of the heart and the location of the cardiac apex in coronary angiography.
There is an anatomical variation of the origin of OM1 where this artery arises at the bifurcation of the left coronary artery where this artery takes the name “ramus intermedius”
Sources:
1. "Gray's Anatomy" 38th British Ed. Churchill Livingstone 1995
2. “Variable anatomy of the right coronary artery supply to the left ventricle” Adams, J. Treasure, T. Thorax 1985;40:618-623
4. "Anatomy of the Human Body" Henry Gray 1918. Philadelphia: Lea & Febiger
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The term "obtuse margin" refers to the superolateral border of the anterior surface of the heart. It is also known by its Latin name [margo obtusus].
The name of this border or margin of the heart is quite descriptive. If you observe the accompanying image, the angle formed between the anterior or sternocostal surface of the heart with the left lateral or left pulmonary surface of the heart, you can see that the angle between these two surfaces is more than 90 degrees, therefore an "obtuse" angle. The corresponding border between these two surfaces has to be called the "obtuse margin"!
In relation to the obtuse margin of the heart we can usually find the first branch that arises from the circumflex artery. This artery is called Obtuse Marginal 1 or OM1.
Click on the image for a larger depiction. Here is a link to an article on the "acute margin" of the heart.
Sources:
1 "Tratado de Anatomia Humana" Testut et Latarjet 8 Ed. 1931 Salvat Editores, Spain
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Anterior view of the heart
The acute marginal artery is the longest branch of the right coronary artery on the anterior aspect of the heart and extends towards the cardiac apex. The name reflects the fact that this artery runs along the anteroinferior border of the heart called the “margo acutus” in Latin or the “acute margin”.
The acute marginal artery is used in coronary angiography to denote the lower border of the heart.
The acute marginal artery may have a higher origin on the right coronary artery or it may arise from one of the lower right ventricular arteries. There are anatomical variations of the acute marginal artery where this artery actually may provide blood supply to the left ventricle of the heart.
Sources:
1. "Gray's Anatomy" 38th British Ed. Churchill Livingstone 1995
2. “Variable anatomy of the right coronary artery supply to the left ventricle” Adams, J. Treasure, T. Thorax 1985;40:618-623
4. "Anatomy of the Human Body" Henry Gray 1918. Philadelphia: Lea & Febiger
Image modified by CAA, Inc. Original image courtesy of bartleby.com
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Anterior view of the heart
The great cardiac vein is one of the longest veins of the coronary system of the heart. It arises close to the cardiac apex in the anterior interventricular sulcus and ascends parallel to the anterior interventricular artery (LAD). The great cardiac vein will end in the most proximal portion of the coronary sinus. At this point the coronary sinus presents with an “entrance” valve called the “coronary valve of Vieussens”
In some cases the great cardiac vein will anastomose with the middle cardiac vein creating a collateral circulation venous drainage system that includes the coronary sinus.
There are several anatomical variations of the great cardiac vein.
Sources:
1 "Tratado de Anatomia Humana" Testut et Latarjet 8 Ed. 1931 Salvat Editores, Spain
2. “The great cardiac vein” Peikovic, B. Surg Radiol Anat. 1992;14(1):23-8.
3. “Great cardiac vein variations” Bales, GS Clin Anat. 2004 Jul;17(5):436-43p>Source:
4. "Anatomy of the Human Body" Henry Gray 1918. Philadelphia: Lea & Febiger
Image modified by CAA, Inc. Original image courtesy of bartleby.com