Medical Terminology Daily (MTD) is a blog sponsored by Clinical Anatomy Associates, Inc. as a service to the medical community. We post anatomical, medical or surgical terms, their meaning and usage, as well as biographical notes on anatomists, surgeons, and researchers through the ages. Be warned that some of the images used depict human anatomical specimens.
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Georg Eduard Von Rindfleisch
(1836 – 1908)
German pathologist and histologist of Bavarian nobility ancestry. Rindfleisch studied medicine in Würzburg, Berlin, and Heidelberg, earning his MD in 1859 with the thesis “De Vasorum Genesi” (on the generation of vessels) under the tutelage of Rudolf Virchow (1821 - 1902). He then continued as a assistant to Virchow in a newly founded institute in Berlin. He then moved to Breslau in 1861 as an assistant to Rudolf Heidenhain (1834–1897), becoming a professor of pathological anatomy. In 1865 he became full professor in Bonn and in 1874 in Würzburg, where a new pathological institute was built according to his design (completed in 1878), where he worked until his retirement in 1906.
He was the first to describe the inflammatory background of multiple sclerosis in 1863, when he noted that demyelinated lesions have in their center small vessels that are surrounded by a leukocyte inflammatory infiltrate.
After extensive investigations, he suspected an infectious origin of tuberculosis - even before Robert Koch's detection of the tuberculosis bacillus in 1892. Rindfleisch 's special achievement is the description of the morphologically conspicuous macrophages in typhoid inflammation. His distinction between myocardial infarction and myocarditis in 1890 is also of lasting importance.
Associated eponyms
"Rindfleisch's folds": Usually a single semilunar fold of the serous surface of the pericardium around the origin of the aorta. Also known as the plica semilunaris aortæ.
"Rindfleisch's cells": Historical (and obsolete) name for eosinophilic leukocytes.
Personal note: G. Rindfleisch’s book “Traité D' Histologie Pathologique” 2nd edition (1873) is now part of my library. This book was translated from German to French by Dr. Frédéric Gross (1844-1927) , Associate Professor of the Medicine Faculty in Nancy, France. The book is dedicated to Dr. Theodore Billroth (1829-1894), an important surgeon whose pioneering work on subtotal gastrectomies paved the way for today’s robotic bariatric surgery. Dr. Miranda.
Sources:
1. "Stedmans Medical Eponyms" Forbis, P.; Bartolucci, SL; 1998 Williams and Wilkins
2. "Rindfleisch, Georg Eduard von (bayerischer Adel?)" Deutsche Biographie
3. "The pathology of multiple sclerosis and its evolution" Lassmann H. (1999) Philos Trans R Soc Lond B Biol Sci. 354 (1390): 1635–40.
4. “Traité D' Histologie Pathologique” G.E.
Rindfleisch 2nd Ed (1873) Ballieres et Fils. Paris, Translated by F Gross
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This article is part of the series "A Moment in History" where we honor those who have contributed to the growth of medical knowledge in the areas of anatomy, medicine, surgery, and medical research.
John Benjamin Murphy
Dr. John Benjamin Murphy (1857 – 1916). An American surgeon, John Benjamin Murphy was born in Appleton, Wisconsin in 1857. He studied anatomy and physiology in Appleton under the care of Dr. H.W. Reilly, a local physician, after which J.B. Murphy entered the Rush Medical College, receiving his degree in 1879.
Urged by the new trends in surgery and antisepsis, in 1882 Dr. Murphy he traveled to Vienna to study with Theodor Billroth (1829 – 1894), and then on to Heidelberg and Berlin. Upon his return, he started great advances in the surgery of the time. One of them was to propose the immediate extirpation of the vermiform appendix when acute appendicitis was diagnosed, as opposed to the common practice of waiting until the vermiform appendix ruptured.
In 1892 Dr. Murphy became professor of clinical surgery at the College of Physicians and Surgeons in Chicago. Dr. Murphy is one of the founders of the American College of Surgeons. His surgical endeavors span many specialties including abdominal, thoracic, peripheral vascular, orthopedics, neurosurgery, etc.
One of his well-known inventions was a metal sutureless compression anastomotic device, known to many as the “Murphy button”. Although in 1826 Denans and Henroz had created metal compression anastomotic devices with a similar concept, Murphy’s improvements on the device caused it to be used well into the 1900’s. The reason for this is the support the device had from the Mayo brothers, founders of the today well-known Mayo Clinic. Although not a stapler, the Murphy button established the need for anastomotic leakage control and the possibility of and end-to-end anastomosis. This makes Dr. Murphy's concept part of the history of surgical stapling. For an image of the Murphy anastomotic device click here, the link is courtesy of the Museum of Health Care at Kingston, Canada.
Murphy’s first use for his device was for a cholecystojejunostomy, the anastomosis of the gallbladder to the jejunum to allow drainage of the bile into the digestive system.
His name is remembered in many eponyms: Murphy’s button, Murphy’s drip, Murphy’s test, Murphy’s punch, and the Murphy-Lane bone skid.
Sources:
1. “Cholecystointestinal, gastrointestinal, enterintestinal anastomosis, and approximation without sutures” Murphy JB. Med Rec (1892) 42: 665
2 . “John Benjamin Murphy – Pioneer of gastrointestinal anastomosis” Bhattacharya, K., & Bhattacharya, N. (2008). Indian J. Surg., 70, 330-333.
3. “The Story of Surgery” Graham, H. (1939) New York: Doubleday, Doran & Co.. Inc.
4. “Compression Anastomosis: History and Clinical Considerations”Kaidar-Person, O, et al, e. (2008) Am J Surg, 818-826.
5. “Current Practice of Surgical Stapling” Ravitch, M. M., Steichen, F. M., & Welter, R. (1991) Philadelphia: Lea& Febiger.
6. “Rese¤as Históricas: John Benjamin Murphy” Parquet, R.A. Acta Gastroenterol Latinoam 2010;40:97
Image in the public domain. National Library of Medicine
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The word [taphophile] arises from the Greek word [τάφος] (táfos) meaning “grave” or “sepulchre”, forming the root term [taph-]. It is completed with the suffix [(o)phile] which also arises from the Greek word [φιλία] meaning “friendship” or “affection”. A taphophile is a person who has affection for the study of graves or tombs. Probably a simpler way of describing this word is to say that a taphophile is a grave or a cemetery tourist. Our good friend Theo Dirix is a taphophile.
It must be understood that this is not a pathology, but rather personal development through the study of the meaning, markings, beauty, art, sculpture, topography, etc., of graves, tombs, tombstones, and cemeteries.
The root term [taph-] can also be found in the following words:
- Taphophilia: An attraction or liking for graves.
- Taphophobia: A pathological fear of graves and cemeteries. Also, the fear of being buried alive.
- Taphonomy: The study of decay, a subspecialty of anthropology.
Note: The links to Google Translate include an icon that will allow you to hear the pronunciation of the word.
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Theo Dirix
Theo Dirix is an author and taphophile. He has successively held the office of Consul in Embassies of Belgium in Tanzania, Saudi Arabia, Jordan, Canada, the United Arab Emirates and, since 2011, Greece. Before 1989, he worked for the Flemish Radio 3 and commented on (mainly Moroccan) literature. He is constantly writing travel stories of his visits to cemeteries and graves.
Theo Dirix became directly involved in the quest to find the grave of Andreas Vesalius on the island of Zakynthos in Greece and as the Consul of Belgium was critical to the realization of the 2014 Vesalius Continuum meeting on the same island.
The same year (2014) Theo Dirix published his book "IN SEARCH OF ANDREAS VESALIUS; The Quest for the lost grave", a detailed story of the process of zeroing on the location of the grave, the politics of the island tourism, and the history and research on Vesalius' death.
Andreas Vesalius did not die returning from Jerusalem on a deserted beach in the Ionian Sea, the only victim of a shipwreck. He did not travel to the Holy Land under pressure of the Inquisition, neither as penance nor escape: he went there as a devout pilgrim with the support of his employer. Weakened by his stay and by his unfortunate return journey, he died in Zakynthos where he was buried in the Santa Maria delle Grazie Church. This and many other details are found in his book and research.
Thanks to Theo Dirix for collaborating with "Medical Terminology Daily" with the article "In Search of Andreas Vesalius, The Quest for the Lost Grave - The Sequel" which he co-authored with Pascale Pollier and Dr. Sylviane Déderix. Here is a link to all the articles in this website where Theo is mentioned.
Following are some links to Theo Dirix's articles on the Internet:
The Quest for Andreas Vesalius' Grave
Visiting a cemetery
Theo Dirix at Academia.edu
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Pascale Pollier
Pascale Pollier is a sculptor/artist who is interested in the melding of art and science. A Belgian National, she studied fine art and Painting in St Lucas art school in Ghent, Blgium and subsequently postgraduate training with the Medical Artists Association, London UK.
She was president and co-founder of BIOMAB (Biological and Medical Art in Belgium) . In 2010 the international collaboration program "Art Researches Science" was created, organizing exhibitions, dissection drawing classes, collaborative art/science projects, symposiums and conferences. The International collaboration partners are: Universities of Antwerp, London, Dundee, Strasbourg and New York.
Pascale is also an external examiner for the medical art course at The Centre for Anatomy & Human Identification, University of Dundee. She is President of the AEIMS (Association Europeenes des lllustrateurs Medicaux et Scientifiques). She works and lives in London as an artist. You can visit her website "artem medicalis" here.
Her art can be best expressed in the words of Jac Scott in his book "Language of Mixed-Media Sculpture": "Pascalle Pollier creates poetic 3D renditions of anatomically referenced 'body maps' that celebrate human life and death. The immediacy of the subject matter and her ability to capture realism provoke reactions from quietly unsettling to outrage. Her work is not for the faint-hearted - its honesty in its clear intent confronts all who gaze at the wonder of the human form in its various states of undress - shedding clothes or skin.... Pollier approaches form a medical science perspective". For images of her work, visit MEDinART.
Her nationality and studies guided her to Andreas Vesalius and with Theo Dirix and other collaborators Pascale was instrumental in the realization of the 2014 Vesalius Continuum meeting on the island of Zakynthos, Greece.
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Thanks to her vision and collaborative work, now there is a new bronze sculpture on the island celebrating the famous Flemish (Belgian) anatomist. She is also deeply involved in the quest to find Vesalius' grave on the island. To this effect, and based on the few images we have of Andreas Vesalius, Pascale created a reverse-engineered bust of Vesalius which depicts what his skull might look like. Several bronze copies of this piece of art are today in exhibits in libraries and museums around the world. To fund the on-going research to find Vesalius' grave, Pascale is offering five wax copies of the bust for sale.
Thanks to Pascale Pollier for collaborating with "Medical Terminology Daily" with the article "In Search of Andreas Vesalius, The Quest for the Lost Grave - The Sequel" which she co-authored with Theo Dirix and Dr. Sylviane Déderix.
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Sylviane Déderix. Ph.D.
Dr. Sylviane Déderix is a Postdoctoral fellow at Catholic University of Louvain in the Aegean Interdisciplinary Studies Research Group. She has a Ph.D. in History, Art, and Archeology.
She is also a collaborator of the Laboratory of Geophysical- Satellite Remote Sensing & Archaeoenvironment and a member of the Sissi Archaeological Project (Crete, Greece) in charge of the architectural study of the house tombs excavated in the cemetery.
She has collaborated with the effort of finding the lost grave of Andreas Vesalius using satellite imagery and geophysical approaches to pinpoint the location of the cemetery of the Church of Santa Maria delle Grazie after the island of Zakynthos was practically destroyed by an earthquake in 1953.
Since then the island and its buildings have been rebuilt and streets relocated, which causes the cemetery to have been lost until her work was published. Now we know the approximate location of the cemetery close to the current intersection of the Kolokotroni and Kolyva streets, and further studies can be conducted.
Thanks to Dr. Déderix for collaborating with "Medical Terminology Daily" with the article "In Search of Andreas Vesalius, The Quest for the Lost Grave - The Sequel" which she co-authored with Pascale Pollier and Theo Dirix.
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Article by Dr. Sylviane Déderix, Pascale Pollier, and Theo Dirix
Sylviane Déderix. Ph.D.
From 4 until 8 September 2014, more than two hundred artists and scientists from more than 40 countries gathered on the Greek Island of Zakynthos to commemorate the quincentenary of the Flemish anatomist Andreas Vesalius who died on the island 450 years earlier. At this very moment when some start dreaming of a sequel of our Vesalius Continuum Conference, we continue to dream of the sequel of our search for his lost grave. The triennial of 2017 will be an ideal occasion to present a second phase in our search, on condition that the plan we are developing here succeeds.
The initial phase of the search for the Vesalius’s grave, started and presented in 2014, was based on recent re-examinations of historical sources that contest the traditional view that Vesalius was buried at Laganas. Research by the Flemish historians Omer Steeno, Maurits Biesbrouck, Theodoor Goddeeris and the local historical blogger Pavlos Plessas indeed suggest that the quest for his grave should rather focus on the town of Zakynthos, and more specifically on the courtyard of the church of Santa Maria delle Grazie.
Pascale Pollier
Unfortunately, the small church was destroyed along with most of the buildings in Zakynthos during the major earthquake that struck the Ionian Islands in 1953. Its ruins were then buried when the town was reconstructed, and its exact location was soon forgotten. Material evidence, local informants and cartographic data nevertheless point in the same direction: the church of Santa Maria delle Grazie would have been located in the northern sector of the modern town, around the current junction of Kolokotroni and Kolyva streets.
In order to assess the validity of this hypothesis, we called on the services of Geographic Information Systems (abbreviated GIS). GIS are computer-based tools used for the management, analysis, and display of geographically referenced information. Within the framework of the quest for Vesalius’ lost grave, they were used to overlay historical maps on modern cartographic data. The procedure, which is named geo-referencing, allows registering individual maps in a common geographic space so as to define their position in the real world. In the present case, the goal was to geo-reference a town map dated to 1892 and on which the church can be identified. See the accompanying photograph of the church.
Theo Dirix
However, since the coastline and the town plan drastically changed after the earthquake, it was not possible to overlay the particular map directly onto modern satellite images: intermediary steps were necessary. The methodology consisted therefore in travelling back in time and geo-referencing three available maps from the most recent to the oldest. The result of the process confirmed that the ruins of the Santa Maria delle Grazie are to be found to the northwest of the intersection of the current Kolyva and Kolokotroni streets. The road that ran in front of the church in the late 19th and early 20th century followed a different orientation than Kolyva street, with the consequence that the church lies partly below the street and partly below private properties.
This small GIS project represents only a first phase in the quest for Vesalius’ grave. Phase 2 would be to conduct a geophysical prospection at the Kolyva/Kolokotroni intersection. By making use of non-destructive geophysical methods, we could get an idea of what is still lying under the modern surface, and at which depth. This would provide a fast and high resolution understanding of the area. In an urban environment, two techniques can be used: Ground Penetrating radar and Electrical Resistivity Tomography, which measure the propagation of electromagnetic waves and of the electrical current in the ground, respectively. If the geophysical results were conclusive, the possibility of small-scale excavations (Phase 3) could be considered.
Click for a larger image
The GIS was sponsored by Agfa HealthCare, the Greek subsidiary of the Belgian Agfa Gevaert Group, the Belgian University of Antwerp, and Theo Dirix. For the consequent phases, Pascale Pollier offers to sell five original wax models of her facial reconstruction of Andreas Vesalius. This inversed reconstruction of Vesalius’s skull, based on his portrait, will have to suffice until we find his skull, allowing her to reconstruct his real face. Vesalius Continuum, initially the conference where we launched the search of Vesalius’s grave, has evolved in a programme to which you can contribute.
Personal note: My sincere thanks to Dr. Déderix, Pascale Pollier, and Theo Dirix for contributing this article to "Medical Terminology Daily" and the quest to find and study Andreas Vesalius' grave. I am proud to have been one of the many international attendees to the 2014 meeting in the island of Zakynthos. Dr. Miranda.